Evidence map›Paper›PMID 33469821›Full record

ArticleMolecular and cellular biochemistry2021

Protective effects of luteolin on the venous endothelium.

Henrique Charlanti Reis Assunção, Yan Milen Coelho Cruz, Jéssica Silva Bertolino, Raphael Caio Tamborelli Garcia, Liliam Fernandes

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Targeting L-arginine/NO/cGMP/KFrontiers in pharmacology · 2025
    Review
  2. Nutrients · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Henrique Charlanti Reis AssunçãoDepartamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, Diadema, SP, 09913-030, Brazil.
Yan Milen Coelho CruzDepartamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, Diadema, SP, 09913-030, Brazil.
Jéssica Silva BertolinoDepartamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, Diadema, SP, 09913-030, Brazil.
Raphael Caio Tamborelli GarciaDepartamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, Diadema, SP, 09913-030, Brazil.
Liliam FernandesDepartamento de Ciências Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Campus Diadema, Diadema, SP, 09913-030, Brazil. lfernandes@unifesp.br.ORCID http://orcid.org/0000-0002-4051-5012

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luteolin is a flavonoid with antioxidant properties already demonstrated in studies related to inflammation, tumor, and cardiovascular processes; however, there are no available information regarding its antioxidant effects at the venous endothelial site. We investigated the effects of luteolin (10, 20, and 50 μmol/L) in cultures of rat venous endothelial cells. Nitric oxide (NO) and reactive oxygen species (ROS) were analyzed by fluorimetry; 3-nitrotyrosine (3-NT) residues were evaluated by immunofluorescence, and prostacyclin (PGI

Indexed as

AnimalsAntioxidantsEndothelium, VascularLuteolinNitric OxideRatsReactive Oxygen SpeciesVenae CavaeAntioxidantsLuteolinNitric OxideReactive Oxygen Species3-NTLuteolinNitric oxideProstacyclinSuperoxideVenous endothelium

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.