Observational studyDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2021
Evaluation of the potential environmental risk from the destination of medicines: an epidemiological and toxicological study.
Observational study in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Determinants of Medication Storage and Disposal Practices in Brazil: A Cross-Sectional Study with Implications for Environmental Exposure.Epidemiologia (Basel, Switzerland) · 2026Article
- Disposal practices for unused and expired medications among outpatients in three healthcare facilities in Ibadan, Nigeria: a cross-sectional analysis.BMC public health · 2025Article
- Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- The magnitude and associated factors of unused medications storage practice among households in Jimma city, southwest of Ethiopia: Community-based cross-sectional study.Exploratory research in clinical and social pharmacy · 2024Article
- Guidance provided by pharmacists to customers regarding to destination of unused household medications: disposal of household medications.BMC health services research · 2023Article
- Environmental impacts of COVID-19 treatment: Toxicological evaluation of azithromycin and hydroxychloroquine in adult zebrafish.The Science of the total environment · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe high consumption of medicines by the population and their storage at home might cause an increase in the number of pharmaceutical substances that may be inappropriately discarded in the sanitary sewage, reaching an environmental aquatic. Thus, the effects of these emerging contaminants need more studies.
objectivesTo identify the profile of most medicines that are discarded by users of community pharmacy and evaluate the toxicity of the most disposed drugs.
methodsThis was a translational study. A descriptive observational study was carried out for convenience of community pharmacy users using a standardized questionnaire. Subsequently, the lethal concentration 50 (LC
resultsMost respondents (96%) had a "home pharmacy." The primary forms of disposal were in the common household waste, kitchen sink, and/or bathroom. The medicines that were most incorrectly discarded by the interviewees were nimesulide (17.1%), dipyrone (10.7%), and paracetamol (5.2%). LC
conclusionRespondents disposed medicines in an inappropriate manner primarily in household waste and in the toilet. Nimesulide was the most discarded drug according to study population. Moreover, teratogenic effects such as spinal cord defects, decreasing heartbeats, and increasing pericardial and yolk sac area in embryos were observed after exposure to nimesulide. These results show that nimesulide may promote risk to aquatic organisms and to human health if it is discarded in an unsafe manner.
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Registered trials
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