ArticleCancer management and research2021
Distance Between the Tumour and Nipple as a Predictor of Axillary Lymph Node Involvement in Breast Cancer.
Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Association between MRI-based tumor-to-skin distance and axillary lymph node metastasis in breast cancer.Turkish journal of medical sciences · 2026Article
- Ultrasonic features of automated breast volume scanner (ABVS) and handheld ultrasound (HHUS) combined with molecular biomarkers in predicting axillary lymph node metastasis of clinical T1-T2 breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- Intramammary Tumor Location and Ipsilateral Lymphatic Spread in Early Breast Cancer Patients Using One-Step Nucleic Acid Amplification (OSNA) Assay.The breast journal · 2024Observational
- Expanded indications for breast-conserving surgery with oncoplastic approaches compared to conventional approaches: a single-center retrospective comparative cohort study.Gland surgery · 2023Article
- Tumor Characteristics Associated with Axillary Nodal Positivity in Triple Negative Breast Cancer.Diseases (Basel, Switzerland) · 2023Article
- How to accurately preoperative screen nipple-sparing mastectomy candidate-a nomogram for predicting nipple-areola complex involvement risk in breast cancer patients.World journal of surgical oncology · 2023Article
- Factors Influencing Lymph Node Positivity in HER2/neu+ Breast Cancer Patients.Current oncology (Toronto, Ont.) · 2023Article
- Basosquamous Cell Carcinoma of the Nipple-Areola Complex-Report of a Case.Medicina (Kaunas, Lithuania) · 2023Article
- Real-world outcomes for Chinese breast cancer patients with tumor location of central and nipple portion.Frontiers in surgery · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe possibility of axillary node metastasis via the lymphatics might be related to a cancer's location within the breast. Previous studies of this topic had small sample sizes, inaccuracies because of subjective differences, and the inability to depict the entire three-dimensional structure of the breast. Here, we aimed to improve upon these existing drawbacks by retrospectively analysing whether tumour location (quadrants) and tumour-nipple distance can predict axillary node positivity. PATIENTS AND
methodsWe identified 961 patients with invasive breast cancer between January 2000 and April 2016. The tumour-nipple distance was objectively measured intraoperatively and clinicopathological information was extracted from hospital database. The distance was measured radially from the nipple to the epicentre rather than the edge of tumour to obviate confounders resulting from tumour size variations.
resultsA total of 847 breast cancers (839 patients) met the eligibility criteria and were included in the statistical analysis. The tumour-nipple distance was smaller in node-positive patients (n = 307; 2.76 ± 2.07 cm) than in node-negative patients (n = 297; 3.41 ± 2.18 cm) (
conclusionTumour-nipple distance can be used to predict axillary lymph node metastasis and assist in surgical decision-making and therapy planning. However, exploratory studies are required to increase our understanding of the mechanism.
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