Evidence map›Paper›PMID 33469351›Full record

ArticleInternational journal of general medicine2021

Impact of Combined Photo-Biomodulation and Aerobic Exercise on Cognitive Function and Quality-of-Life in Elderly Alzheimer Patients with Anemia: A Randomized Clinical Trial.

Ebtesam N Nagy, Ahmed Y Ali, Mervat E Behiry, Mervat M Naguib, Marwa M Elsayed

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04496778 (The Beneficial Effect of Low Level Laser Therapy Combined With Nasal Irradiation on Cognitive Function and Quality of Life in Alzheimer Anemic Elderly Patients), which is not on this map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04496778 nacompletednot on this map

The Beneficial Effect of Low Level Laser Therapy Combined With Nasal Irradiation on Cognitive Function and Quality of Life in Alzheimer Anemic Elderly Patients

TypeinterventionalSponsorCairo UniversityRan2020 to 2020Enrolled60ConditionsAlzheimer Disease, Cognitive Impairment, MildArmslow level laser therapy ( laser acupuncture combined with nasal laser irradiation), aerobic exercise
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ebtesam N NagyPhysical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Ahmed Y AliInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Mervat E BehiryInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.ORCID 0000-0002-3718-7994
Mervat M NaguibInternal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Marwa M ElsayedPhysical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.ORCID 0000-0002-1854-6541
Cairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFew data are available on the positive impact of photo-biomodulation (PBM) using low-level laser therapy as a complementary treatment for improving the cognitive function and optimizing the hemoglobin (Hb) level and oxygen carrying capacity in anemic elderly patients and consequently improving the quality-of-life. The present study aimed to evaluate a new, safe, and easy therapeutic approach to improve Alzheimer's disease-related symptoms that interfere with the whole life activities and social interaction of elderly patients. PATIENTS AND

methodsIn this placebo-controlled clinical trial, 60 elderly patients suffering from anemia and mild cognitive dysfunction were randomly assigned into two equal groups to receive active or placebo low-level laser in addition to a moderate-intensity aerobic exercise over a 12-week period. Hb level as well as cognitive and functional tests were reassessed for any change after 12 weeks of intervention.

resultsBy the end of this study, both groups showed significant improvements in Hb level, Montreal Cognitive Assessment Scale (MoCa - B basic), Quality-of-Life for Alzheimer's Disease scale, and Berg Balance scale scores along with significant reduction in body mass index (BMI) and waist-hip ratio (WHR) (

conclusionCombined low-level laser therapy and moderate-intensity aerobic exercises are more effective in improving the cognitive function and quality-of-life of Alzheimer's disease patients. CLINICAL

trial registrationwww.ClinicalTrials.gov, identifier NCT04496778.

Indexed as

Alzheimer’s diseasecognitionexerciselaserquality of life

Identifiers

PMID33469351
PMCPMC7813463
OpenAlexW3120742569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.