ArticleNeuropsychiatric disease and treatment2021
Clinical Manifestations, Fluid Changes and Neuroimaging Alterations in Patients with General Paresis of the Insane.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- Prognostic predictors in HIV-negative neurosyphilis: a retrospective cohort study with prospective follow-up.BMC infectious diseases · 2026Article
- Correlation analysis of psychiatric and behavioral symptoms with cognitive impairment and prognosis in patients with general paresis.Frontiers in psychiatry · 2026Article
- Neurosyphilis and Parkinsonism: Overlapping Pathophysiology and Emerging Therapeutic Insights.Current neurovascular research · 2026Review
- White Matter Integrity in General Paresis: An Exploratory Tract-Based Spatial Statistical Analysis.Neuropsychiatric disease and treatment · 2026Article
- Clinical, Radiological, and Pathological Features of Cerebral and Spinal Syphilitic Gumma: A Cross-Sectional Study.International journal of general medicine · 2025Article
- Clinical spectrum of late symptomatic neurosyphilis in China: an 11-year retrospective study.Sexually transmitted infections · 2024Article
- Selective attention function impairment in HIV-negative patients with early forms of neurosyphilis.European journal of medical research · 2024Article
- Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Ocular findings in neurosyphilis: a retrospective study from 2012 to 2022.Frontiers in neurology · 2024Article
- Clinical and Laboratory Characteristics, Diagnosis, and Treatment of Patients with Neurosyphilis in Emergency Department: A Retrospective Study of 12 Patients.Infection and drug resistance · 2024Article
- Investigation of Gray Matter Changes Using Voxel-Based Morphometry in HIV-Negative Patients with General Paresis of the Insane.Neuropsychiatric disease and treatment · 2024Article
- Clinical Insights into Neurosyphilis Patients with Leptomeningeal Enhancement of Spinal Cord.Neuropsychiatric disease and treatment · 2024Article
- Clinical and Laboratory Characteristics, Neuroimaging Alternations and Treatment Response of 25 HIV-Negative General Paresis Patients.Infection and drug resistance · 2023Article
- Neuropsychological Features in Patients with General Paresis of the Insane at an Early Stage.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aim to study the clinical manifestations, fluid changes and neuroimaging alterations in patients with general paresis of the insane (GPI).
methodsA total of 119 patients suffering from GPI recruited in Beijing Ditan Hospital, Capital Medical University from 2010 to 2020 were retrospectively analyzed.
resultsIn 119 GPI patients, 103 cases (86.6%) were male. Misdiagnosed rate was up to 83.2%, schizophrenia and mood disorders were the most common misdiagnosed diseases. Duration from symptom onset to the final confirmed diagnosis was 10.4±12.9 months. The main clinical manifestations included cognitive impairment (114 cases, 95.8%) and neuropsychiatric symptoms (107 cases, 90.0%). The cognitive domains including the delayed recall, visuospatial/executive function and language ability indicated by MoCA score were damaged severely. Rapid plasma regain (RPR) of all GPI patients was 100% positive in serum and 89.9% positive in cerebral spinal fluid (CSF). The white blood cell (WBC) number in CSF was between 6 and 50/μL in 73 GPI patients (61.3%). The protein level was between 45.1 and 70mg/dL in 47 cases (39.5%). In the 110 cases, 96 cases (87.3%) were abnormal indicated by cerebral atrophy mostly located in the anterior brain and abnormal signals distributed in various regions of the brain mostly in the frontal lobe and temporal lobe.
conclusionThe symptoms of GPI were complex and easy to misdiagnose. The clinicians were still short of vigilance for neurosyphilis. We should expand serologic testing for syphilis especially in patients with cognitive impairment and neuropsychiatric symptoms. We suggest syphilis curricula in the training program of the clinicians especially for neurologist and psychiatrist.
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