Evidence map›Paper›PMID 33469285›Full record

ReviewInternational journal of nanomedicine2021

Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects.

Muhammad Ikram, Bilal Javed, Naveed Iqbal Raja, Zia-Ur-Rehman Mashwani

Open access · goldAbstract readReview
In one paragraph

Review in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 220 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. The selenium-enrichedFrontiers in microbiology · 2026
    Article
  7. Article
  8. The selenium paradox friend or foe in breast cancer?Annals of medicine and surgery (2012) · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Muhammad Ikram *Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan.
Bilal Javed *Department of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan.ORCID 0000-0002-9566-1498
Naveed Iqbal RajaDepartment of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan.
Zia-Ur-Rehman MashwaniDepartment of Botany, PMAS Arid Agriculture University, Rawalpindi, Punjab 46300, Pakistan.ORCID 0000-0003-4222-7708
Pir Mehr Ali Shah Arid Agriculture University · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium nanoparticles (SeNPs) have advantages over other nanomaterials because of the promising role of selenium in the stabilization of the immune system and activation of the defense response. The use of SeNPs and their supplements not only have pharmacological significance but also boost and prepare the body's immune system to fight the pathogens. This review summarizes the recent progress in the biogenesis of plant-based SeNPs by using various plant species and the role of secondary metabolites on their biocompatible functioning. Phyto-synthesis of SeNPs results in the synthesis of nanomaterials of various, size, shape and biochemical nature and has advantages over other routine physical and chemical methods because of their biocompatibility, eco-friendly nature and in vivo actions. Unfortunately, the plant-based SeNPs failed to attain considerable attention in the pharmaceutical industry. However, a few studies were performed to explore the therapeutic potential of the SeNPs against various cancer cells, microbial pathogens, viral infections, hepatoprotective actions, diabetic management, and antioxidant approaches. Further, some of the selenium-based drug delivery systems are developed by engineering the SeNPs with the functional ligands to deliver drugs to the targeted sites. This review also provides up-to-date information on the mechanistic actions that the SeNPs adopt to achieve their designated tasks as it may help to develop precision medicine with customized treatment and healthcare for the ailing population.

Indexed as

AnimalsAntioxidantsDrug Delivery SystemsHumansHypoglycemic AgentsNanoparticlesPlantsSeleniumAntioxidantsHypoglycemic AgentsSeleniumcancerdiabetesdrug deliverygreen synthesisreactive oxygen speciesSeNPs

Identifiers

PMID33469285
PMCPMC7811472
OpenAlexW3119707626

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.