ArticlePatient preference and adherence2021
A Difficult Pill to Swallow: An Investigation of the Factors Associated with Medication Swallowing Difficulties.
Article in Patient preference and adherence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05522101 (Mini-sized Magnetically Controlled Capsule Endoscopy vs. Normal-sized CE for Detection of Small Bowel in Children Under the Age of 10 Years：A Prospective，Multi-center，Randomized Controlled Trial), which is not on this map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mini-sized Magnetically Controlled Capsule Endoscopy vs. Normal-sized CE for Detection of Small Bowel in Children Under the Age of 10 Years：A Prospective，Multi-center，Randomized Controlled Trial
Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Prescribing for the patient and the planet: a pragmatic feasibility study of a behaviour change intervention to reduce liquid amoxicillin prescribing in primary care.Exploratory research in clinical and social pharmacy · 2026Article
- Discriminating Isolated Pill Dysphagia from General Oropharyngeal Dysphagia: Psychometric Properties of the Turkish PILL-5.Dysphagia · 2026Article
- A qualitative study exploring the views of healthcare professionals regarding patients who have difficulty swallowing medicines.International journal of clinical pharmacy · 2026Article
- Prevalence and Characteristics of Pill Dysphagia in Adults with Swallowing Disorders: A FEES Based Retrospective Study.Dysphagia · 2026Article
- The Omega-3 Index and Self-Reported Dietary Intake of DHA and EPA in Highly Trained, Elite and World Class (Tier 3-5) Male and Female Athletes: An Australian Based Cross-sectional Study.Sports medicine - open · 2026Article
- Fabrication of Microneedle Patches by Suspension Casting of Drugs in Organic Solvents.Pharmaceutics · 2026Article
- Using sentiment analysis to quantify the relative desirability and acceptability of drug-product attributes.JAMIA open · 2026Article
- Oral capsule administration of biomacromolecules that achieves bioavailability and pharmacokinetics comparable to subcutaneous injection in dogs - the BIONDDDrug delivery and translational research · 2026Article
- Oral Medication Swallowing in Dysphagia: Prevalence of Penetration, Aspiration, Residue, and Epiglottic Morphology Impact-A Retrospective Study.Progress in rehabilitation medicine · 2026Article
- Detection and management of pill swallowing difficulties: a community pharmacy-based observational study.International journal of clinical pharmacy · 2025Observational
- High-velocity delivery of biologics via the gastrointestinal tract by self-pressurized oral capsules.Journal of controlled release : official journal of the Controlled Release Society · 2025Article
- Ibrutinib oral suspension bioavailability and compatibility for optimal enteral administration route.Therapeutic advances in hematology · 2025Article
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- Evaluation of the Effect of Benzydamine Hydrochloride on the Intensity of Gag Reflex: A Randomized Single-Blind Clinical Trial.Journal of dentistry (Shiraz, Iran) · 2024Article
- Implementing a medication lubricant for pill dysphagia on an acute care ward using Plan-Do-Study-Act cycles.BMJ open quality · 2023Article
- Development of an Administration Guideline of Oral Medicines to Patients with Dysphagia.Medicina (Kaunas, Lithuania) · 2023Article
- Dysphagia and pill swallowing in HIV/AIDS in South Africa: Results of a scoping review.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2023Article
- The Use of Calcium Phosphate-Based Starter Pellets for the Preparation of Sprinkle IR MUPS Formulation of Rosuvastatin Calcium.Pharmaceuticals (Basel, Switzerland) · 2023Article
- KidzMed e-learning to upskill student pharmacists to teach pill swallowing to children.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany medications are available as solid oral dosage forms such as tablets and capsules; however, some people find these medications difficult to swallow.
aimTo identify whether certain psychological, oral sensory, and oral motor characteristics contribute to medication swallowing difficulties.
methodsA sample of healthy adults from two academic institutions in Brisbane were assessed for their experiences with swallowing solid oral dosage forms, food preferences, and food neophobia. The gag reflex, oral cavity size, fungiform papillae count, and chewing efficacy were also evaluated followed by a capsule-swallowing task. Primary outcome was the incidence of medication swallowing difficulties. Secondary outcomes were the association of medication swallowing difficulties with psychological, oral sensory, and oral motor factors.
resultsOf 152 subjects, 32% reported difficulty swallowing tablets or capsules whole. This group was significantly more likely to have had a memory of choking on medications compared to those without medication swallowing difficulties (OR = 7.25, p < 0.05). Current medication swallowing difficulties were significantly associated with a smaller mouth cavity size (OR = 2.98, p < 0.05), a higher density of taste receptors on the tongue (OR = 3.27, p < 0.05), and were higher among those who chewed a jelly candy to non-homogenous particle size (OR = 4.1, p < 0.05). Current medication swallowing difficulties were associated with lower confidence in swallowing large capsules (000 size: OR = 0.47, 00 size: OR = 0.39, p < 0.05). No associations were found between medication swallowing difficulties and the gag reflex or food neophobia.
conclusionA combination of heightened oral perception characterized by a small oral cavity and high taste sensitivity compounded by a past choking episode on medications may be precipitating factors for medication swallowing difficulties. These factors may be helpful in identifying individuals who are more likely to experience difficulty swallowing medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.