ArticleCommunications biology2021
Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson's disease.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 81 citations in OpenAlex.
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- A high-resolution functional network-organized atlas of human superficial white matter from ultra-high-field diffusion MRI.iScience · 2026Article
- Longitudinal Degeneration of Microstructural and Structural Connectivity Patterns Following Stroke.Stroke · 2026Article
- Variations of structural-functional coupling in post-traumatic stress disorder are associated with underlying molecular and transcriptional features.Psychological medicine · 2026Article
- Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.Communications medicine · 2026Article
- Longitudinal Multimodal Neuroimaging After Traumatic Brain Injury.Human brain mapping · 2026Article
- Structural-functional connectivity coupling in motor-brain networks following acute ischemic stroke.Journal of neuroengineering and rehabilitation · 2026Article
- Linking cortical morphology and neurophysiological dynamics in Parkinson's disease.Scientific reports · 2026Article
- Brain imaging reveals hierarchical topology changes and stage-dependent impairments in autoimmune encephalitis.Journal of neurology · 2026Article
- Evidence for divergent cortical organisation in Parkinson's disease and Lewy Body Dementia.Nature communications · 2025Article
- Linking Cortical Morphology and Neurophysiological Dynamics in Parkinson's Disease.Research square · 2025Article
- Brain Microstructural Alterations in Children Post-COVID-19 Infection Through VBM, SBM, and Structural Covariance Network Analysis.Brain and behavior · 2025Article
- Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease.bioRxiv : the preprint server for biology · 2025Article
- Excitation-inhibition balance abnormally shapes structure-function coupling of gray matter in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- The overgrowth of structure-function coupling in premature brain during infancy.Developmental cognitive neuroscience · 2025Article
- Visual hallucinations in Parkinson's disease: spotlight on central cholinergic dysfunction.Brain : a journal of neurology · 2025Review
- Dopamine alters functional gradients in Parkinson's disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Disruption of structural connectome hierarchy in age-related hearing loss.Frontiers in neuroscience · 2025Article
- Partial correlation as a tool for mapping functional-structural correspondence in human brain connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Structural-functional connectivity decoupling in multiscale brain networks in Parkinson's disease.BMC neuroscience · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Parkinson's dementia is characterised by changes in perception and thought, and preceded by visual dysfunction, making this a useful surrogate for dementia risk. Structural and functional connectivity changes are seen in humans with Parkinson's disease, but the organisational principles are not known. We used resting-state fMRI and diffusion-weighted imaging to examine changes in structural-functional connectivity coupling in patients with Parkinson's disease, and those at risk of dementia. We identified two organisational gradients to structural-functional connectivity decoupling: anterior-to-posterior and unimodal-to-transmodal, with stronger structural-functional connectivity coupling in anterior, unimodal areas and weakened towards posterior, transmodal regions. Next, we related spatial patterns of decoupling to expression of neurotransmitter receptors. We found that dopaminergic and serotonergic transmission relates to decoupling in Parkinson's overall, but instead, serotonergic, cholinergic and noradrenergic transmission relates to decoupling in patients with visual dysfunction. Our findings provide a framework to explain the specific disorders of consciousness in Parkinson's dementia, and the neurotransmitter systems that underlie these.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.