ArticleScientific reports2021
Elevated inflammatory gene expression in intervertebral disc tissues in mice with ADAM8 inactivated.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of Age on Intervertebral Disc Tissue Morphology and Gene Expression in the ADAM8-Inactivation Mouse.Cells · 2026Article
- Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner.JOR spine · 2026Article
- Modest Effects of Age on Inflammatory Markers and Histological Features in the Murine Intervertebral Disc Injury Model.American journal of physical medicine & rehabilitation · 2025Article
- ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc.Genes & diseases · 2025Article
- Gene Expression Changes Precede Elevated Mechanical Sensitivity in the Mouse Intervertebral Disc Injury Model.JOR spine · 2025Article
- ADAM8 inactivation retards intervertebral disc degeneration in mice.Genes & diseases · 2024Article
- Gene Expression Profiles Perturbed by Injury to the Mouse Intervertebral Disc.American journal of physical medicine & rehabilitation · 2024Article
- Serum antioxidant enzymes in spinal stenosis patients with lumbar disc herniation: correlation with degeneration severity and spinal fusion rate.BMC musculoskeletal disorders · 2023Article
- Recent advances in the repair of degenerative intervertebral disc for preclinical applications.Frontiers in bioengineering and biotechnology · 2023Review
- Expression of Human Interleukin 8 in Mice Alters Their Natural Behaviors.Journal of inflammation research · 2022Article
- Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
We found ADAM8 enzymatic activity elevated in degenerative human intervertebral disc (IVD). Here, we examined the discs in ADAM8-inactivation mice that carry a mutation preventing self-activation of the enzyme. Surprisingly, elevated gene expression for inflammatory markers (Cxcl1, IL6) was observed in injured discs of ADAM8 mutant mice, along with elevated expression of type 2 collagen gene (Col2a1), compared with wild type controls. Injured annulus fibrosus of mutant and wild type mice contained a higher proportion of large collagen fibers compared with intact discs, as documented by microscopic examination under circular polarized light. In the intact IVDs, Adam8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.