Evidence map›Paper›PMID 33469056›Full record

ArticleScientific reports2021

Clinical and laboratory features of hypercoagulability in COVID-19 and other respiratory viral infections amongst predominantly younger adults with few comorbidities.

Chuen Wen Tan, Jing Yuan Tan, Wan Hui Wong, May Anne Cheong, Ian Matthias Ng, Edwin Philip Conceicao, Jenny Guek Hong Low, Heng Joo Ng, Lai Heng Lee

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  4. Comprehensive Analysis of Cardiovascular Events and Risk Factors in Patients Hospitalized With Respiratory Syncytial Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chuen Wen Tan *Department of Haematology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore. tan.chuen.wen@singhealth.com.sg.
Jing Yuan Tan *SingHealth Internal Medicine Residency, Singapore General Hospital, Singapore, Singapore.
Wan Hui WongDepartment of Haematology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
May Anne CheongDepartment of Haematology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
Ian Matthias NgDepartment of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore, Singapore.
Edwin Philip ConceicaoDepartment of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore, Singapore.
Jenny Guek Hong LowDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Heng Joo NgDepartment of Haematology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
Lai Heng LeeDepartment of Haematology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
Singapore General Hospital · SGSingHealth · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and other respiratory viral (non-CoV-2-RV) infections are associated with thrombotic complications. The differences in prothrombotic potential between SARS-CoV-2 and non-CoV-2-RV have not been well characterised. We compared the thrombotic rates between these two groups of patients directly and further delved into their coagulation profiles. In this single-center, retrospective cohort study, all consecutive COVID-19 and non-CoV-2-RV patients admitted between January 15th and April 10th 2020 were included. Coagulation parameters studied were prothrombin time and activated partial thromboplastin time and its associated clot waveform analysis (CWA) parameter, min1, min2 and max2. In the COVID-19 (n = 181) group there were two (1.0 event/1000-hospital-days) myocardial infarction events while one (1.8 event/1000-hospital-day) was reported in the non-CoV-2-RV (n = 165) group. These events occurred in patients who were severely ill. There were no venous thrombotic events. Coagulation parameters did not differ throughout the course of mild COVID-19. However, CWA parameters were significantly higher in severe COVID-19 compared with mild disease, suggesting hypercoagulability (min1: 6.48%/s vs 5.05%/s, P < 0.001; min2: 0.92%/s

Indexed as

AdultCOVID-19FemaleHumansMaleMyocardial InfarctionPartial Thromboplastin TimeProthrombin TimeRetrospective StudiesRisk FactorsSARS-CoV-2Severity of Illness IndexThrombophiliaVirus Diseases

Identifiers

PMID33469056
PMCPMC7815883
OpenAlexW3124658321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.