ArticleNature communications2021
Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development.
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In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
What it found
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review.Acta neurochirurgica · 2023Pooled it
- Ablation of the choroid plexus attenuates hydrocephalus-induced parenchymal edema with moderate reduction of postnatal hippocampal neurogenesis.Fluids and barriers of the CNS · 2026Article
- Choroid plexus inflammation in bipolar disorder.Brain, behavior, and immunity · 2026Article
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus.Fluids and barriers of the CNS · 2026Article
- Serial failure of the brain clearance continuum in Alzheimer's disease: mechanisms and therapeutic perspectives.Journal of neurology · 2026Review
- Article
- Arrested hydrocephalus and beyond: advances in the pathophysiology, diagnosis, and management of various forms of chronic hydrocephalus: a comprehensive narrative review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Increased CSF volume, altered brain development and emotional reactivity after postnatal Zika virus infection in infant rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Regulation of Choroid Plexus Bicarbonate Transporters Following Intraventricular Hemorrhage in Mice.Cell biochemistry and function · 2026Article
- BMAL1-GPX3 axis in the choroid plexus mitigates Aβ pathology in an amyloid mouse model.Journal of neuroinflammation · 2026Article
- Age-related molecular and functional remodeling of the choroid plexus in the gray mouse lemur.PloS one · 2026Article
- Adeno-associated viruses (AAVs) induce dose-dependent neonatal ventriculomegaly following intracerebroventricular administration.bioRxiv : the preprint server for biology · 2025Article
- Aberrant adenosine ANature communications · 2025Article
- Selective vulnerability of GABAergic neurons in chronic migraine.The journal of headache and pain · 2025Article
- The Role of Choroid Plexus in Hydrocephalus from the Perspective of Structure and Function: a Therapeutic Target.Molecular neurobiology · 2025Review
- Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development.Nature neuroscience · 2025Article
- Molecular hallmarks of hydrocephalus.Science translational medicine · 2025Review
- Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer's disease.Molecular neurodegeneration · 2025Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 1 country.
Huixin Xu *Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0003-4190-4244
Ryann M Fame *Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0002-8244-2624
Cameron SadeghDepartment of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0003-2231-9015
Jason SutinFetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Christopher NaranjoSummer Honors Undergraduate Research Program, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
Della SyauSummer Honors Undergraduate Research Program, Division of Medical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
Jin CuiDepartment of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.
Frederick B ShipleyDepartment of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.
Amanda VernonBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Fan GaoBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Yong ZhangPulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
Michael J HoltzmanPulmonary and Critical Care Medicine, Department of Medicine, Washington University, St. Louis, MO, 63110, USA.
Myriam HeimanBroad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.
Benjamin C WarfDepartment of Neurosurgery, Boston Children's Hospital, Boston, MA, 02115, USA.
Pei-Yi LinFetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.
Maria K LehtinenDepartment of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA. maria.lehtinen@childrens.harvard.edu.ORCID 0000-0002-7243-2967
Boston Children's Hospital · USBroad Institute · USHarvard University · USWashington University in St. Louis · US
Funding
Viral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Gabriel Kreiman · 1998 to 2026
$21.3MDefining and Controlling Airway DiseaseR35HL145242 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2019 to 2025
$6.6MControl of neural stem cells by the nascent cerebrospinal fluidR01NS088566 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI LEHTINEN, MARIA · 2014 to 2024
$5.5MMouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SAHIN, MUSTAFA · 2016 to 2020
$5.2MPARP9-DTX3L Control Of Viral Infection and Airway DiseaseR01AI130591 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2017 to 2021
$3.0MImproving infant hydrocephalus outcomes in Uganda: Predicting developmental outcomes and identifying patients at risk for early treatment failure after ETV/CPCR01HD096693 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI LIN, PEI-YI, WARF, BENJAMIN CURTIS · 2018 to 2022
$2.8MPediatric Pathology Translational ResearchT32HL110852 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI FLEMING, MARK D · 2012 to 2017
$1.4MBeside Monitor of Cerebral Metabolism in Premature Infants with Intraventricular R00HD083512 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI LIN, PEI-YI · 2017 to 2019
$740kNEI NIH HHS P30 EY012196NHLBI NIH HHS R35 HL145242NHLBI NIH HHS T32 HL110852NIAID NIH HHS R01 AI130591NICHD NIH HHS R00 HD083512NICHD NIH HHS R01 HD096693NICHD NIH HHS U54 HD090255NINDS NIH HHS R01 NS088566
Abstract
Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neurodevelopment. The mechanisms regulating CSF clearance during the postnatal critical period are unclear. Here, we show that CSF K
Indexed as
AnimalsAnimals, NewbornCerebrospinal FluidChoroid PlexusDependovirusDisease Models, AnimalEmbryo, MammalianFemaleGenetic VectorsHumansHydrocephalusInjections, IntraventricularIntracranial PressureMagnetic Resonance ImagingMaleMiceSlc12a2 protein, mouseSolute Carrier Family 12, Member 2
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.