ArticleNature communications2021
Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 56 citations in OpenAlex.
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- Polysulfamates as "Macroisosteres" of Polyurethanes with Improved Degradability.Angewandte Chemie (International ed. in English) · 2025Article
- Advances and challenges in biomaterials for tendon and enthesis repair.Bioactive materials · 2025Review
- Synthesis and Characterization of Photocurable Difunctional Monomers for Medical Applications.Polymers · 2024Article
- Resorbable barrier polymers for flexible bioelectronics.Nature communications · 2023Article
- Hybrid Shear-thinning Hydrogel Integrating Hyaluronic Acid with ROS-Responsive Nanoparticles.Advanced functional materials · 2023Article
- Rational design of poly(peptide-ester) block copolymers for enzyme-specific surface resorption.Journal of materials chemistry. B · 2023Article
- Modifying Poly(caprolactone) Degradation through C-H Functionalization.Macromolecules · 2023Article
- High-speed, scanned laser structuring of multi-layered eco/bioresorbable materials for advanced electronic systems.Nature communications · 2022Article
- Click Step-Growth Polymerization andAccounts of chemical research · 2022Article
- Sugar-Based Polymers with Stereochemistry-Dependent Degradability and Mechanical Properties.Journal of the American Chemical Society · 2022Article
- Click Nucleophilic Conjugate Additions to Activated Alkynes: Exploring Thiol-yne, Amino-yne, and Hydroxyl-yne Reactions from (Bio)Organic to Polymer Chemistry.Chemical reviews · 2021Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.
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