Evidence map›Paper›PMID 33468696›Full record

ArticlemBio2021

Antibiotic-Selected Gene Amplification Heightens Metal Resistance.

David A Hufnagel, Jacob E Choby, Samantha Hao, Anders F Johnson, Eileen M Burd, Charles Langelier, David S Weiss

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Antibiotic resistance mediated by gene amplifications.npj antimicrobials and resistance · 2024
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David A HufnagelEmory Antibiotic Resistance Center, Atlanta, Georgia, USA.
Jacob E ChobyEmory Antibiotic Resistance Center, Atlanta, Georgia, USA.
Samantha HaoDivision of Infectious Diseases, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0002-4349-8131
Anders F JohnsonDepartment of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.
Eileen M BurdEmory Antibiotic Resistance Center, Atlanta, Georgia, USA.ORCID 0000-0002-7055-942X
Charles LangelierDivision of Infectious Diseases, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0002-6708-4646
David S WeissEmory Antibiotic Resistance Center, Atlanta, Georgia, USA david.weiss@emory.edu.ORCID 0000-0003-0980-7866
Emory University · USUniversity of California, San Francisco · US

Funding

Research Training in Translational Gastroenterology and HepatologyT32DK108735 · NIDDK · EMORY UNIVERSITY · PI SUBRA KUGATHASAN · 2016 to 2026
$2.6M
Mechanisms of phenotypic antibiotic resistance in Gram-negative bacteriaR01AI141883 · NIAID · EMORY UNIVERSITY · PI WEISS, DAVID S · 2018 to 2022
$2.2M
Profiling the Lung Transcriptome for Precision Diagnosis of Respiratory Infections using Host/Pathogen Metagenomic SequencingK23HL138461 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2018 to 2021
$718k
NHLBI NIH HHS K23 HL138461NIAID NIH HHS R01 AI141883NIDDK NIH HHS T32 DK108735
6 · The paper itself

Abstract

The increasing frequency of antibiotic resistance poses myriad challenges to modern medicine. Environmental survival of multidrug-resistant bacteria in health care facilities, including hospitals, creates reservoirs for transmission of these difficult to treat pathogens. To prevent bacterial colonization, these facilities deploy an array of infection control measures, including bactericidal metals on surfaces, as well as implanted devices. Although antibiotics are routinely used in these health care environments, it is unknown whether and how antibiotic exposure affects metal resistance. We identified a multidrug-resistant

Indexed as

Anti-Bacterial AgentsBacterial ProteinsColistinDrug Resistance, Multiple, BacterialEnterobacter cloacaeEscherichia coli K12Gene AmplificationGene DuplicationHumansMicrobial Sensitivity TestsNickelTrace ElementsAnti-Bacterial AgentsBacterial ProteinsColistinNickelTrace ElementscolistinEnterobactergene amplificationheteroresistancemetal resistancenickel

Identifiers

PMID33468696
PMCPMC8545094
OpenAlexW3122172284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.