Evidence map›Paper›PMID 33468691›Full record

ArticlemBio2021

Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa.

Jitender Mehla, Giuliano Malloci, Rachael Mansbach, Cesar A López, Ruslan Tsivkovski, Keith Haynes, Inga V Leus, Sally B Grindstaff, Robert H Cascella, Napoleon D'Cunha and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Inhibitor of Chromosome Segregation inACS chemical biology · 2024
    Article
  10. Review
  11. Article
  12. Review
  13. Multidrug efflux pumps ofFrontiers in microbiology · 2024
    Article
  14. Article
  15. Article
  16. The Art of War withAntibiotics (Basel, Switzerland) · 2023
    Review
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 2 countries.

Jitender Mehla *Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Giuliano Malloci *Department of Physics, University of Cagliari, Cagliari, Italy.ORCID 0000-0002-5985-257X
Rachael Mansbach *Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Cesar A LópezTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Ruslan TsivkovskiQpex Biopharma, San Diego, California, USA.
Keith HaynesDepartment of Pharmacology and Physiology, St. Louis University, School of Medicine, St. Louis, Missouri, USA.
Inga V LeusDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Sally B GrindstaffDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Robert H CascellaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.
Napoleon D'CunhaDepartment of Pharmacology and Physiology, St. Louis University, School of Medicine, St. Louis, Missouri, USA.
Liam HerndonDepartment of Pharmacology and Physiology, St. Louis University, School of Medicine, St. Louis, Missouri, USA.
Nicolas W HengartnerTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Enrico MargiottaDepartment of Physics, University of Cagliari, Cagliari, Italy.
Alessio AtzoriDepartment of Physics, University of Cagliari, Cagliari, Italy.
Attilio V VargiuDepartment of Physics, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-4013-8867
Pedro D ManriqueTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
John K WalkerDepartment of Pharmacology and Physiology, St. Louis University, School of Medicine, St. Louis, Missouri, USA.
Olga LomovskayaQpex Biopharma, San Diego, California, USA.ORCID 0000-0001-8637-3139
Paolo RuggeroneDepartment of Physics, University of Cagliari, Cagliari, Italy.ORCID 0000-0003-0825-0824
S GnanakaranTheoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
Valentin V RybenkovDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA.ORCID 0000-0002-5300-4369
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma, USA elenaz@ou.edu.ORCID 0000-0001-8929-4727
University of Oklahoma · USLos Alamos National Laboratory · USUniversity of Cagliari · ITSaint Louis University · US

Funding

Optimization of efflux avoidance and inhibition for antibiotic developmentR01AI136799 · NIAID · UNIVERSITY OF OKLAHOMA · PI GNANAKARAN, SANDRASEGARAM, RUGGERONE, PAOLO · 2018 to 2022
$5.7M
Biacore T200S10OD025014 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI MCEVER, RODGER PAUL · 2018 to 2018
$322k
NIAID NIH HHS R01 AI136799NIH HHS S10 OD025014
6 · The paper itself

Abstract

Antibiotic-resistant bacteria rapidly spread in clinical and natural environments and challenge our modern lifestyle. A major component of defense against antibiotics in Gram-negative bacteria is a drug permeation barrier created by active efflux across the outer membrane. We identified molecular determinants defining the propensity of small peptidomimetic molecules to avoid and inhibit efflux pumps in

Indexed as

Models, BiologicalAnti-Bacterial AgentsBacterial Outer Membrane ProteinsBinding SitesBiological TransportDrug Resistance, Multiple, BacterialGene ExpressionKineticsMembrane Transport ProteinsMicrobial Sensitivity TestsModels, MolecularPeptidomimeticsPrincipal Component AnalysisProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandAnti-Bacterial AgentsBacterial Outer Membrane ProteinsMembrane Transport ProteinsMexB protein, Pseudomonas aeruginosaPeptidomimeticsantibiotic resistancemachine learning modelsmultidrug effluxouter membranePseudomonas aeruginosa

Identifiers

PMID33468691
PMCPMC7845643
OpenAlexW3125286984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.