Evidence map›Paper›PMID 33468680›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the

Molly J McBride, Sarah R Pope, Kai Hu, C Denise Okafor, Emily P Balskus, J Martin Bollinger, Amie K Boal

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Heme Oxygenase-Like Metalloenzymes.Annual review of biochemistry · 2025
    Review
  15. Biochemical characterization of the self-sacrificing p-aminobenzoate synthase from Nitrosomonas europaea reveals key residues involved in selecting a Fe/Fe or Mn/Fe cofactor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Article
  16. Copper-chelating natural products.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Molly J McBrideDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802.ORCID https://orcid.org/0000-0003-3832-1355
Sarah R PopeDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.ORCID https://orcid.org/0000-0002-2756-4530
Kai HuDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802.ORCID https://orcid.org/0000-0002-6555-2581
C Denise OkaforDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802; cdo5093@psu.edu balskus@chemistry.harvard.edu jmb21@psu.edu akb20@psu.edu.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138 cdo5093@psu.edu balskus@chemistry.harvard.edu jmb21@psu.edu akb20@psu.edu.
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; cdo5093@psu.edu balskus@chemistry.harvard.edu jmb21@psu.edu akb20@psu.edu.
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802; cdo5093@psu.edu balskus@chemistry.harvard.edu jmb21@psu.edu akb20@psu.edu.
Pennsylvania State University · USHarvard University · US

Funding

Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
The biosynthesis of N-N bond-containing natural productsR01GM132564 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2020 to 2023
$1.5M
Structures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3M
NIGMS NIH HHS R01 GM132564NIGMS NIH HHS R01 GM138580NIGMS NIH HHS R35 GM119707NIH HHS S10 OD012289
6 · The paper itself

Abstract

In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates

Indexed as

CatalysisCrystallography, X-RayHeme Oxygenase (Decyclizing)HumansLigandsNitrosourea CompoundsNonheme Iron ProteinsOxidation-ReductionOxygenOxygenasesPancreatic NeoplasmsProtein ConformationProtein DomainsStreptozocinHeme Oxygenase (Decyclizing)LigandsNitrosourea CompoundsNonheme Iron ProteinsOxygenOxygenasesStreptozocinbioinformaticsN-oxygenasestreptozotocinX-ray crystallography

Identifiers

PMID33468680
PMCPMC7848743
OpenAlexW3124154166

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.