Evidence map›Paper›PMID 33468665›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

IMITATION SWITCH is required for normal chromatin structure and gene repression in PRC2 target domains.

Masayuki Kamei, Abigail J Ameri, Aileen R Ferraro, Yael Bar-Peled, Fangzhou Zhao, Christina L Ethridge, Kathleen Lail, Mojgan Amirebrahimi, Anna Lipzen, Vivian Ng and 4 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
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  4. HISTONE DEACETYLASE-1 is required for epigenome stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
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  8. Comparative Genomic Analysis Reveals Key Changes in the Genome ofInternational journal of molecular sciences · 2024
    Article
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  18. Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Review
  20. The histone code of the fungal genusMicrobial genomics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Masayuki KameiDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID http://orcid.org/0000-0003-4090-1834
Abigail J AmeriDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID http://orcid.org/0000-0001-5319-2630
Aileen R FerraroDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID http://orcid.org/0000-0003-0918-4486
Yael Bar-PeledDepartment of Microbiology, University of Georgia, Athens, GA 30602.ORCID http://orcid.org/0000-0002-4904-5571
Fangzhou ZhaoDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9040.ORCID http://orcid.org/0000-0001-9124-0138
Christina L EthridgeDepartment of Genetics, University of Georgia, Athens, GA 30602.
Kathleen LailUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Mojgan AmirebrahimiUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Anna LipzenUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Vivian NgUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Igor V GrigorievUS Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID http://orcid.org/0000-0002-3136-8903
Robert J SchmitzDepartment of Genetics, University of Georgia, Athens, GA 30602.ORCID http://orcid.org/0000-0001-7538-6663
Yi LiuDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9040.ORCID http://orcid.org/0000-0002-8801-9317
Zachary A LewisDepartment of Microbiology, University of Georgia, Athens, GA 30602; zlewis@uga.edu.ORCID http://orcid.org/0000-0002-1735-8266
University of Georgia · USLawrence Berkeley National Laboratory · USThe University of Texas Southwestern Medical Center · US

Funding

Mechanisms of Circadian Clock and Gene Sliencing in NeurosporaR35GM118118 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, YI · 2016 to 2025
$6.3M
Transcriptional repression by Polycomb Repressive Complex 2R01GM132644 · NIGMS · UNIVERSITY OF GEORGIA · PI LEWIS, ZACHARY · 2019 to 2022
$1.6M
NIGMS NIH HHS R01 GM132644NIGMS NIH HHS R35 GM118118
6 · The paper itself

Abstract

Polycomb Group (PcG) proteins are part of an epigenetic cell memory system that plays essential roles in multicellular development, stem cell biology, X chromosome inactivation, and cancer. In animals, plants, and many fungi, Polycomb Repressive Complex 2 (PRC2) catalyzes trimethylation of histone H3 lysine 27 (H3K27me3) to assemble transcriptionally repressed facultative heterochromatin. PRC2 is structurally and functionally conserved in the model fungus

Indexed as

Adenosine TriphosphatasesChromatinGene SilencingHeterochromatinHistonesMethylationNeurospora crassaPolycomb-Group ProteinsPolycomb Repressive Complex 2Protein Processing, Post-TranslationalTranscription FactorsAdenosine TriphosphatasesChromatinHeterochromatinHistonesISWI proteinPolycomb-Group ProteinsPolycomb Repressive Complex 2Transcription Factorschromatin remodelingfacultative heterochromatinH3K27me3IMITATION SWITCH (ISWI)Polycomb Repressive Complex 2 (PRC2)

Identifiers

PMID33468665
PMCPMC7848606
OpenAlexW3121575777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.