Evidence map›Paper›PMID 33468652›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Synaptotagmin-1-, Munc18-1-, and Munc13-1-dependent liposome fusion with a few neuronal SNAREs.

Karolina P Stepien, Josep Rizo

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Integrative multi-omics identifiesPsychological medicine · 2026
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  6. A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  13. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Roles for diacylglycerol in synaptic vesicle priming and release revealed by complete reconstitution of core protein machinery.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Karolina P StepienDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID https://orcid.org/0000-0003-0373-8919
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Jose.Rizo-Rey@UTSouthwestern.edu.ORCID https://orcid.org/0000-0003-1773-8311
The University of Texas Southwestern Medical Center · US

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

Neurotransmitter release is governed by eight central proteins among other factors: the neuronal SNAREs syntaxin-1, synaptobrevin, and SNAP-25, which form a tight SNARE complex that brings the synaptic vesicle and plasma membranes together; NSF and SNAPs, which disassemble SNARE complexes; Munc18-1 and Munc13-1, which organize SNARE complex assembly; and the Ca

Indexed as

AnimalsCalciumGene Expression RegulationLiposomesMembrane FusionMunc18 ProteinsNerve Tissue ProteinsNeuronsNeurotransmitter AgentsPhospholipidsRatsSynaptic TransmissionSynaptic VesiclesSynaptosomal-Associated Protein 25Synaptotagmin ISyntaxin 1CalciumLiposomesMunc18 ProteinsNerve Tissue ProteinsNeurotransmitter AgentsPhospholipidsSnap25 protein, ratStxbp1 protein, ratSynaptosomal-Associated Protein 25Synaptotagmin ISyntaxin 1Syt1 protein, ratUnc13a protein, ratVamp2 protein, ratVesicle-Associated Membrane Protein 2membrane fusionneurotransmitter releasereconstitutionsynaptic vesicle fusionsynaptotagmin-1

Identifiers

PMID33468652
PMCPMC7848701
OpenAlexW3123751918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.