Evidence map›Paper›PMID 33468631›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Symmetrical arrangement of proteins under release-ready vesicles in presynaptic terminals.

Abhijith Radhakrishnan, Xia Li, Kirill Grushin, Shyam S Krishnakumar, Jun Liu, James E Rothman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Article
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  4. Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
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  7. Review
  8. Article
  9. Article
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  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. All SNAP25 molecules in the vesicle-plasma membrane contact zone change conformation during vesicle priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Diacylglycerol-dependent hexamers of the SNARE-assembling chaperone Munc13-1 cooperatively bind vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abhijith RadhakrishnanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0001-8107-3487
Xia LiDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520.
Kirill GrushinDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520.
Shyam S KrishnakumarDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520; shyam.krishnakumar@yale.edu jliu@yale.edu james.rothman@yale.edu.ORCID 0000-0001-6148-3251
Jun LiuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520; shyam.krishnakumar@yale.edu jliu@yale.edu james.rothman@yale.edu.ORCID 0000-0003-3108-6735
James E RothmanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06520; shyam.krishnakumar@yale.edu jliu@yale.edu james.rothman@yale.edu.

Funding

Regulation of Membrane Fusion in ExocytosisR01DK027044 · NIDDK · YALE UNIVERSITY · PI KRISHNAKUMAR, SHYAM S · 1986 to 2021
$8.2M
Structure-Function Relationships in the Spirochetal Flagellar MotorR01AI087946 · NIAID · YALE UNIVERSITY · PI LIU, JUN · 2010 to 2025
$6.6M
MECHANISMS OF INTRACELLULAR MEMBRANE FUSIONR37DK027044 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, JAMES · 1992 to 2012
$5.3M
High-throughput electron cryo-microscopeS10OD023603 · OD · YALE UNIVERSITY · PI SIGWORTH, FREDERICK J · 2018 to 2018
$1.9M
NIAID NIH HHS R01 AI087946NIDDK NIH HHS R01 DK027044NIDDK NIH HHS R37 DK027044
6 · The paper itself

Abstract

Controlled release of neurotransmitters stored in synaptic vesicles (SVs) is a fundamental process that is central to all information processing in the brain. This relies on tight coupling of the SV fusion to action potential-evoked presynaptic Ca

Indexed as

AnimalsCells, CulturedCryoelectron MicroscopyHippocampusImaging, Three-DimensionalMiceMice, Inbred C57BLNerve Tissue ProteinsNeuronsPresynaptic TerminalsSynaptic VesiclesNerve Tissue Proteinscryoelecton tomographySNARE proteinsynaptic vesiclesvesicle priming

Identifiers

PMID33468631
PMCPMC7865176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.