ArticleJournal of clinical microbiology2021
Assessment of Sample Pooling for Clinical SARS-CoV-2 Testing.
Article in Journal of clinical microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Nonenzymatic Detection of SARS-CoV‑2 RNA Using DNA Nanoswitches.ACS nano medicine · 2026Article
- Enhancing RT-PCR Throughput and Sensitivity through Large-Scale Sample Pooling Using a Nano-Hybrid Membrane.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Strategies for Scaling up SARS-CoV-2 Molecular Testing Capacity.Clinics in laboratory medicine · 2022Review
- Novel Assays for Molecular Detection of Severe Acute Respiratory Syndrome Coronavirus 2.Clinics in laboratory medicine · 2022Review
- Comparative Evaluation of Six SARS-CoV-2 Real-Time RT-PCR Diagnostic Approaches Shows Substantial Genomic Variant-Dependent Intra- and Inter-Test Variability, Poor Interchangeability of Cycle Threshold and Complementary Turn-Around Times.Pathogens (Basel, Switzerland) · 2022Article
- Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic.Emerging microbes & infections · 2021Review
- Pooled Testing Strategies for SARS-CoV-2 diagnosis: A comprehensive review.Diagnostic microbiology and infectious disease · 2021Review
- Optimizing noninvasive sampling of a zoonotic bat virus.Ecology and evolution · 2021Article
- High-sensitivity SARS-CoV-2 group testing by digital PCR among symptomatic patients in hospital settings.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021Article
- Enhanced throughput of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time RT-PCR panel by assay multiplexing and specimen pooling.Journal of virological methods · 2021Article
- Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance.PLoS computational biology · 2021Article
- Pooling of Samples for SARS-CoV-2 Detection Using a Rapid Antigen Test.Frontiers in tropical diseases · 2021Article
- Considerations for Pooled Testing of Employees for SARS-CoV-2.Journal of occupational and environmental medicine · 2021Article
- Modelling pool testing for SARS-CoV-2: addressing heterogeneity in populations.Epidemiology and infection · 2020Article
- Evaluation and Comparison of the Hologic Aptima SARS-CoV-2 Assay and the CDC 2019-nCoV Real-Time Reverse Transcription-PCR Diagnostic Panel Using a Four-Sample Pooling Approach.Journal of clinical microbiology · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accommodating large increases in sample workloads has presented a major challenge to clinical laboratories during the coronavirus disease 2019 (COVID-19) pandemic. Despite the implementation of automated detection systems and previous efficiencies, including barcoding, electronic data transfer, and extensive robotics, capacities have struggled to meet the demand. Sample pooling has been suggested as an additional strategy to address this need. The greatest concern with this approach in clinical settings is the potential for reduced sensitivity, particularly detection failures with weakly positive samples. To investigate this possibility, detection rates in pooled samples were evaluated, with a focus on pools containing weakly positive specimens. Additionally, the frequencies of occurrence of weakly positive samples during the pandemic were reviewed. Weakly positive specimens, with threshold cycle (
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Registered trials
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