Evidence map›Paper›PMID 33468585›Full record

ReviewInfection and immunity2021

Living in Your Skin: Microbes, Molecules, and Mechanisms.

Mary Hannah Swaney, Lindsay R Kalan

Open access · greenAbstract readReview
In one paragraph

Review in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. V- and VNature communications · 2026
    Article
  6. Article
  7. Review
  8. Dextran-based stimuli-responsive hydrogels for smart dressings in wound healing.Journal of materials science. Materials in medicine · 2026
    Review
  9. Seed Oil ofInternational journal of molecular sciences · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. The Role ofInternational journal of molecular sciences · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mary Hannah SwaneyDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Lindsay R KalanDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA lkalan@wisc.edu.ORCID 0000-0003-4980-5128
University of Wisconsin–Madison · US

Funding

Microbial Pathogenesis &Host Responses Training ProgramT32AI055397 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KLEIN, BRUCE STEVEN · 2003 to 2024
$5.5M
Elucidating the Role of Microbial Community Dynamics in Wound Repair and RegenerationR35GM137828 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KALAN, LINDSAY ROBYN · 2020 to 2021
$750k
NIAID NIH HHS T32 AI055397NIGMS NIH HHS R35 GM137828
6 · The paper itself

Abstract

Human skin functions as a physical, chemical, and immune barrier against the external environment while also providing a protective niche for its resident microbiota, known as the skin microbiome. Cooperation between the microbiota, host skin cells, and the immune system is responsible for maintenance of skin health, and a disruption to this delicate balance, such as by pathogen invasion or a breach in the skin barrier, may lead to impaired skin function. In this minireview, we describe the role of the microbiome in microbe, host, and immune interactions under distinct skin states, including homeostasis, tissue repair, and wound infection. Furthermore, we highlight the growing number of diverse microbial metabolites and products that have been identified to mediate these interactions, particularly those involved in host-microbe communication and defensive symbiosis. We also address the contextual pathogenicity exhibited by many skin commensals and provide insight into future directions in the skin microbiome field.

Indexed as

BiomarkersMicrobiotaSkin Physiological PhenomenaCell CommunicationEnergy MetabolismHomeostasisHost-Pathogen InteractionsHumansImmune SystemOrgan SpecificitySkinWound HealingBiomarkershost-microbe interactionmicrobial ecologyskin microbiomespecialized metabolitewound infection

Identifiers

PMID33468585
PMCPMC8090955
OpenAlexW3125336323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.