ArticleInfection and immunity2021
Murine Intrarectal Instillation of Purified Recombinant
Open access · greenAbstract read
In one paragraph
Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 18 citations in OpenAlex.
- Integrating machine learning and WGCNA to identify core candidate genes and decipher immune-related molecular networks in TcdA/TcdB-associated CDI.Antonie van Leeuwenhoek · 2026Article
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- A single amino acid substitution determines susceptibility ofFrontiers in cellular and infection microbiology · 2026Article
- Clostridioides difficile toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity.Mucosal immunology · 2025Article
- Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection.PLoS pathogens · 2024Article
- Prosurvival Pathway Protects From Clostridioides difficile Toxin-Mediated Cell Death.The Journal of infectious diseases · 2024Article
- Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo.PLoS pathogens · 2023Article
- Article
- Vitamin DAutophagy · 2022Article
- Repurposing epigenetic inhibitors to target theEpigenetics · 2022Article
- Human Colon Cancer-Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice.Cancer discovery · 2022Article
- Clostridioides difficile Toxin B Activates Group 3 Innate Lymphocytes.Infection and immunity · 2022Article
- Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection.PLoS pathogens · 2022Article
- Investigation of metabolic crosstalk between host and pathogenicFrontiers in bioengineering and biotechnology · 2022Article
- Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host.Cell reports · 2021Article
- Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix.Nature communications · 2021Article
- A Palmitoylethanolamide ProducingFrontiers in pharmacology · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Nicholas O Markham *Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-1348-1267
Sarah C Bloch *Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John A Shupe *Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Erin N LaubacherDivision of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Audrey K ThomasDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Heather K KrohDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kevin O ChildressDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
F Christopher Peritore-GalveDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
M Kay WashingtonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Robert J CoffeyDivision of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
D Borden LacyEpithelial Biology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA borden.lacy@vumc.org.ORCID 0000-0003-2273-8121
Vanderbilt University Medical Center · USVanderbilt University · US
Funding
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6MIntegrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MStructural mechanisms of Clostridium difficile pathogenesisR01AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LACY, DANA BORDEN · 2011 to 2020
$3.9MMOLECULAR PARASITOLOGY TRAINING PROGRAMT32AI007281 · NIAID · MEHARRY MEDICAL COLLEGE · PI NDE, PIUS N · 1985 to 2025
$3.2MStructural Mechanisms of Clostridioides difficile pathogenesisR37AI095755 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2021 to 2026
$3.2MThe role of toxins in Clostridium difficile infection pathogenesisI01BX002943 · VA · VETERANS HEALTH ADMINISTRATION · PI LACY, DANA BORDEN · 2016 to 2025
–BLRD VA I01 BX002943NCI NIH HHS P50 CA236733NCI NIH HHS R35 CA197570NIAID NIH HHS R01 AI095755NIAID NIH HHS R37 AI095755NIAID NIH HHS T32 AI007281NIDDK NIH HHS P30 DK058404NIDDK NIH HHS T32 DK007673
Abstract
PubMed holds no abstract for this paper.
Indexed as
Disease SusceptibilityAnimalsBacterial ProteinsBacterial ToxinsClostridioides difficileColonDisease Models, AnimalEnterocolitis, PseudomembranousEnterotoxinsHumansImmunohistochemistryIntestinal MucosaMiceMutant ProteinsRecombinant ProteinsBacterial ProteinsBacterial ToxinsEnterotoxinsMutant ProteinsRecombinant ProteinstcdA protein, Clostridium difficiletoxB protein, Clostridium difficileacute colitisbacterial toxinClostridioides difficilemouse model
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.