Evidence map›Paper›PMID 33468581›Full record

ArticleInfection and immunity2021

Ectopic Expression of Human Thymosin β4 Confers Resistance to Legionella pneumophila during Pulmonary and Systemic Infection in Mice.

Bonggoo Park, Min Hwa Shin, Jiyoung Kim, Gayoung Park, Yun-Kyoung Ryu, Jae-Wook Lee, Tae Jin Kim, Eun-Yi Moon, Kyung-Mi Lee

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bonggoo Park *Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
Min Hwa Shin *Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
Jiyoung Kim *Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
Gayoung ParkDepartment of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
Yun-Kyoung RyuDepartment of Bioscience and Biotechnology, Sejong University, Seoul, South Korea.
Jae-Wook LeeDepartment of Bioscience and Biotechnology, Sejong University, Seoul, South Korea.
Tae Jin KimDepartment of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea.
Eun-Yi MoonDepartment of Bioscience and Biotechnology, Sejong University, Seoul, South Korea eunyimoon@sejong.ac.kr kyunglee@korea.ac.kr.
Kyung-Mi LeeDepartment of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea eunyimoon@sejong.ac.kr kyunglee@korea.ac.kr.ORCID 0000-0002-5378-9258
Korea University · KRSejong University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymosin beta-4 (Tβ4) is an actin-sequestering peptide that plays important roles in regeneration and remodeling of injured tissues. However, its function in a naturally occurring pathogenic bacterial infection model has remained elusive. We adopted Tβ4-overexpressing transgenic (Tg) mice to investigate the role of Tβ4 in acute pulmonary infection and systemic sepsis caused by

Indexed as

Ectopic Gene ExpressionAnimalsCytokinesDisease Models, AnimalDisease ResistanceHost-Pathogen InteractionsHumansImmunohistochemistryImmunophenotypingLegionella pneumophilaLegionnaires' DiseaseLigandsMaleMiceMice, TransgenicPneumonia, BacterialCytokinesLigandsThymosinThymosin beta(4)Toll-Like Receptorsanti-inflammatorybactericidalLegionella pneumophilapulmonary infectionsepsisthymosin β4

Identifiers

PMID33468581
PMCPMC8090946
OpenAlexW3126079684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.