Evidence map›Paper›PMID 33468580›Full record

ArticleInfection and immunity2021

The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a

Duah Alkam, Piroon Jenjaroenpun, Aura M Ramirez, Karen E Beenken, Horace J Spencer, Mark S Smeltzer

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Adaptive microevolution in CC17Frontiers in cellular and infection microbiology · 2026
    Article
  2. Microorganisms · 2025
    Review
  3. Article
  4. The ability ofInfection and immunity · 2025
    Article
  5. Article
  6. Article
  7. The major role ofVirulence · 2023
    Article
  8. Regulatory Functions of PurR inMicroorganisms · 2023
    Article
  9. Review
  10. StaphylococcalInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Duah AlkamDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Piroon JenjaroenpunDepartment of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-1555-401X
Aura M RamirezDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Karen E BeenkenDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Horace J SpencerDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Mark S SmeltzerDepartment of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA smeltzermarks@uams.edu.ORCID 0000-0002-0878-0692
University of Arkansas for Medical Sciences · US

Funding

Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Pilot Grant ProgramP30GM145393 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI MARK S SMELTZER · 2022 to 2026
$7.6M
Impact of Staphylococcus aureus in osteomyelitis and bone physiologyR01AI119380 · NIAID · UNIV OF ARKANSAS FOR MED SCIS · PI BEENKEN, KAREN E., SMELTZER, MARK S · 2015 to 2025
$4.1M
NIAID NIH HHS R01 AI119380NIGMS NIH HHS P20 GM103625NIGMS NIH HHS P30 GM145393
6 · The paper itself

Abstract

Mutation of

Indexed as

MutationAnimalsBacterial ProteinsBiofilmsDisease SusceptibilityDNA Transposable ElementsEndopeptidasesExtracellular SpaceGene Expression Regulation, BacterialMiceOsteomyelitisRepressor ProteinsStaphylococcal InfectionsStaphylococcus aureusTrans-ActivatorsVirulenceBacterial ProteinsDNA Transposable ElementsEndopeptidasesPurR protein, BacteriaRepressor ProteinsSarA protein, bacterialTrans-ActivatorsVirulence Factorsextracellular proteasesosteomyelitispurRsarAStaphylococcus aureus

Identifiers

PMID33468580
PMCPMC8090970
OpenAlexW3124916438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.