Evidence map›Paper›PMID 33468528›Full record

ArticleBMJ open2021

Causal modelling of variation in clinical practice and long-term outcomes of ADHD using Norwegian registry data: the ADHD controversy project.

Arnstein Mykletun, Tarjei Widding-Havneraas, Ashmita Chaulagain, Ingvild Lyhmann, Ingvar Bjelland, Anne Halmøy, Felix Elwert, Peter Butterworth, Simen Markussen, Henrik Daae Zachrisson and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04799886 (Attitudes Associated to Prescription of ADHD Drugs Among Child and Adolescent Psychiatrists in Region Skåne.), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04799886 completednot on this map

Attitudes Associated to Prescription of ADHD Drugs Among Child and Adolescent Psychiatrists in Region Skåne.

TypeobservationalSponsorLund UniversityRan2021 to 2022Enrolled11ConditionsAttitude, ADHD - Combined Type, Physician's RoleArmsSemi structured interview
3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Psychiatric diagnosis on the edge: is there evidence of benefit?European child & adolescent psychiatry · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A systematic meta-review of systematic reviews on attention deficit hyperactivity disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2023
    Review
  9. Geographical variation in ADHD: do diagnoses reflect symptom levels?European child & adolescent psychiatry · 2023
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arnstein MykletunDepartment of Community Medicine, University of Tromso Faculty of Health Sciences, Tromso, Norway arnstein.mykletun@uit.no.ORCID 0000-0002-3878-0079
Tarjei Widding-HavneraasCentre for Research and Education in Forensic Psychiatry, Haukeland University Hospital, Bergen, Norway.
Ashmita ChaulagainCentre for Research and Education in Forensic Psychiatry, Haukeland University Hospital, Bergen, Norway.
Ingvild LyhmannCentre for Research and Education in Forensic Psychiatry, Haukeland University Hospital, Bergen, Norway.
Ingvar BjellandDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Anne HalmøyDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Felix ElwertDepartment of Sociology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Peter ButterworthResearch School of Population Health, The Australian National University, Canberra, Victoria, Australia.
Simen MarkussenRagnar Frisch Centre for Economic Research, Oslo, Norway.
Henrik Daae ZachrissonDepartment of Special Education, University of Oslo, Oslo, Norway.
Knut RypdalCentre for Research and Education in Forensic Psychiatry, Haukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAttention-deficit/hyperactivity disorder (ADHD) is among the most common mental disorders in children and adolescents, and it is a strong risk factor for several adverse psychosocial outcomes over the lifespan. There are large between-country and within-country variations in diagnosis and medication rates. Due to ethical and practical considerations, a few studies have examined the effects of receiving a diagnosis, and there is a lack of research on effects of medication on long-term outcomes.Our project has four aims organised in four work packages: (WP1) To examine the prognosis of ADHD (with and without medication) compared with patients with other psychiatric diagnoses, patients in contact with public sector child and adolescent psychiatric outpatient clinics (without diagnosis) and the general population; (WP2) Examine within-country variation in ADHD diagnoses and medication rates by clinics' catchment area; and(WP3) Identify causal effects of being diagnosed with ADHD and (WP4) ADHD medication on long-term outcomes. METHOD AND ANALYSIS: Our project links several nationwide Norwegian registries. The patient sample is all persons aged 5-18 years that were in contact with public sector child and adolescent psychiatric outpatient clinics in 2009-2011. Our comparative analysis of prognosis will be based on survival analysis and mixed-effects models. Our analysis of variation will apply mixed-effects models and generalised linear models. We have two identification strategies for the effect of being diagnosed with ADHD and of receiving medication on long-term outcomes. Both strategies rely on using preference-based instrumental variables, which in our project are based on provider preferences for ADHD diagnosis and medication. ETHICS AND DISSEMINATION: The project is approved by the Regional Ethics Committee, Norway (REC number 2017/2150/REC south-east D). All papers will be published in open-access journals and results will be presented in national and international conferences. TRIAL REGISTRATION NUMBERS: ISRCTN11573246 and ISRCTN11891971.

Indexed as

Attention Deficit Disorder with HyperactivityAdolescentCausalityChildChild, PreschoolHumansNorwayRegistrieschild & adolescent psychiatryepidemiologymental health

Identifiers

PMID33468528
PMCPMC7817799

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.