Evidence map›Paper›PMID 33468477›Full record

ArticleAntimicrobial agents and chemotherapy2021

Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria.

Thanaporn Wattanakul, Mark Baker, Joerg Mohrle, Brett McWhinney, Richard M Hoglund, James S McCarthy, Joel Tarning

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Thanaporn WattanakulMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Mark BakerDepartment of Clinical Pharmacology, ViiV Healthcare, Geneva, Switzerland.
Joerg MohrleMedicine for Malaria Venture, Meyrin, Switzerland.ORCID 0000-0002-0769-9649
Brett McWhinneyAnalytical Chemistry Unit, Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
Richard M HoglundMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
James S McCarthyQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Joel TarningMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand joel@tropmedres.ac.ORCID 0000-0003-4566-4030
Mahidol University · THMedicines for Malaria Venture · CHRoyal Brisbane and Women's Hospital · AUThe University of Queensland · AU

Funding

Wellcome TrustWellcome Trust 220211
6 · The paper itself

Abstract

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for

Indexed as

AntimalarialsMalariaMalaria, FalciparumQuinolinesAustraliaHumansNew ZealandPiperazinesPlasmodium falciparumVolunteersAntimalarialspiperaquinePiperazinesQuinolinesantimalarial agentscontrolled human malaria infectioninduced blood-stage malariaP. falciparum malariapharmacodynamicspharmacokineticspharmacologypiperaquinepopulation pharmacokinetics

Identifiers

PMID33468477
PMCPMC8097471
OpenAlexW3126120197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.