Evidence map›Paper›PMID 33468472›Full record

ArticleAntimicrobial agents and chemotherapy2021

Synergistic Rifabutin and Colistin Reduce Emergence of Resistance When Treating Acinetobacter baumannii.

Jiaqi Cheng, Jun Yan, Zeferino Reyna, Matt Slarve, Peggy Lu, Brad Spellberg, Brian Luna

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Ceftazidime retainsmSphere · 2025
    Article
  6. Review
  7. Review
  8. Polymyxins retainAntimicrobial agents and chemotherapy · 2024
    Article
  9. Treatment Strategies of Colistin ResistanceAntibiotics (Basel, Switzerland) · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. New Perspectives on Antimicrobial Agents: Cefiderocol.Antimicrobial agents and chemotherapy · 2021
    Review
  17. Carbapenem-resistantJournal of research in pharmacy practice
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiaqi ChengDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Jun YanDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Zeferino ReynaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Matt SlarveDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Peggy LuDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA.
Brad SpellbergLos Angeles County-USC (LAC+USC) Medical Center, Los Angeles, California, USA.
Brian LunaDepartment of Molecular Microbiology and Immunology, Keck School of Medicine at USC, Los Angeles, California, USA brian.luna@usc.edu.ORCID 0000-0001-6718-4551
Keck Hospital of USC · USLAC+USC Medical Center · US

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
Transferrin Combination Therapy to Address Antimicrobial ResistanceR01AI117211 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SPELLBERG, BRAD J · 2016 to 2019
$2.7M
Characterization of Rifabutin Therapy Against Antibiotic-Resistant BacteriaR01AI139052 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LUNA, BRIAN MICHAEL · 2018 to 2021
$2.4M
NIAID NIH HHS R01 AI117211NIAID NIH HHS R01 AI130060NIAID NIH HHS R01 AI139052
6 · The paper itself

Abstract

Recently, we reported rifabutin hyperactivity against

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsColistinDrug Resistance, Multiple, BacterialDrug SynergismHumansMicrobial Sensitivity TestsRifabutinAnti-Bacterial AgentsColistinRifabutinAcinetobacter baumanniiantibiotic resistancecolistinrifabutin

Identifiers

PMID33468472
PMCPMC8097462
OpenAlexW3122623338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.