Evidence map›Paper›PMID 33468467›Full record

ArticleAntimicrobial agents and chemotherapy2021

The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes.

Daniel Hörömpöli, Catherine Ciglia, Karl-Heinz Glüsenkamp, Lars Ole Haustedt, Hildegard Falkenstein-Paul, Gerd Bendas, Anne Berscheid, Heike Brötz-Oesterhelt

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. [Molecular mechanisms underlying the development and spread of antibiotic resistance].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026
    Review
  2. Negamycin: Nature's Forgotten Antibiotic.ACS infectious diseases · 2026
    Review
  3. Frontiers in microbiology · 2026
    Article
  4. Article
  5. Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research.Angewandte Chemie (International ed. in English) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniel Hörömpöli *Interfaculty Institute of Microbiology and Infection Medicine, Department of Microbial Bioactive Compounds, University of Tuebingen, Tuebingen, Germany.ORCID 0000-0002-5236-8443
Catherine Ciglia *Institute of Pharmaceutical Biology, University of Duesseldorf, Duesseldorf, Germany.
Karl-Heinz GlüsenkampSquarix GmbH, Marl, Germany.
Lars Ole HaustedtAnalytiCon Discovery GmbH, Potsdam, Germany.
Hildegard Falkenstein-PaulPharmaceutical Institute, Department of Pharmaceutical & Cell Biological Chemistry, University of Bonn, Bonn, Germany.
Gerd BendasPharmaceutical Institute, Department of Pharmaceutical & Cell Biological Chemistry, University of Bonn, Bonn, Germany.
Anne BerscheidInterfaculty Institute of Microbiology and Infection Medicine, Department of Microbial Bioactive Compounds, University of Tuebingen, Tuebingen, Germany anne.berscheid@uni-tuebingen.de heike.broetz-oesterhelt@uni-tuebingen.de.ORCID 0000-0003-1585-8715
Heike Brötz-OesterheltInterfaculty Institute of Microbiology and Infection Medicine, Department of Microbial Bioactive Compounds, University of Tuebingen, Tuebingen, Germany anne.berscheid@uni-tuebingen.de heike.broetz-oesterhelt@uni-tuebingen.de.ORCID 0000-0001-9364-1832
German Center for Infection Research · DEUniversity of Bonn · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Negamycin is a natural pseudodipeptide antibiotic with promising activity against Gram-negative and Gram-positive bacteria, including

Indexed as

Amino Acids, DiaminoAnti-Bacterial AgentsCell MembraneEscherichia coliHumansAmino Acids, DiaminoAnti-Bacterial AgentsnegamycinantibioticcalciumDppDtpDEscherichia colimembranenatural productnegamycinpeptide transportersuptake

Identifiers

PMID33468467
PMCPMC8097410
OpenAlexW3125404376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.