Evidence map›Paper›PMID 33468462›Full record

ArticleAntimicrobial agents and chemotherapy2021

The Pup-Proteasome System Protects Mycobacteria from Antimicrobial Antifolates.

Marissa B Guzzo, Qing Li, Hoang V Nguyen, W Henry Boom, Liem Nguyen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Science advances · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marissa B GuzzoDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Qing LiDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Hoang V NguyenDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
W Henry BoomDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Liem NguyenDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA liem.nguyen@case.edu.ORCID 0000-0002-1523-1472
University Hospitals of Cleveland · USUniversity School · US

Funding

TRAINING IN GEOGRAPHIC MEDICINE &INFECTIOUS DISEASET32AI007024 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KAZURA, JAMES WALTER · 1985 to 2020
$4.5M
Folate Metabolism in Mycobacterium tuberculosis Revisited: A Potential Drug TargeR01AI087903 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI NGUYEN, LIEM DUY · 2010 to 2014
$1.9M
A Novel Folate Antagonistic Strategy to Treat Drug Resistant Pseudomonas aeruginosa and EnterobacteriaceaeR21AI119287 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI NGUYEN, LIEM DUY · 2015 to 2016
$436k
NIAID NIH HHS R01 AI087903NIAID NIH HHS R21 AI119287NIAID NIH HHS T32 AI007024
6 · The paper itself

Abstract

Protein turnover via the Pup-proteasome system (PPS) is essential for nitric oxide resistance and virulence of

Indexed as

Anti-Infective AgentsFolic Acid AntagonistsMycobacterium tuberculosisBacterial ProteinsMycobacterium smegmatisProteasome Endopeptidase ComplexAnti-Infective AgentsBacterial ProteinsFolic Acid AntagonistsProteasome Endopeptidase Complexantifolatesmycobacteriumproteasometuberculosis

Identifiers

PMID33468462
PMCPMC8097441
OpenAlexW3123433201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.