Evidence map›Paper›PMID 33468194›Full record

ArticleJournal of neuroinflammation2021

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis.

Lin Luo, Xianzhen Hu, Michael L Dixon, Brandon J Pope, Jonathan D Leavenworth, Chander Raman, William R Meador, Jianmei W Leavenworth

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
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  6. Review
  7. Development of semisynthetic saponin immunostimulants.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Structure-Activity Relationship Study ofJournal of medicinal chemistry · 2022
    Article
  12. Review
  13. Current Advances in Follicular Regulatory T-Cell Biology.Critical reviews in immunology · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Follicular Helper CD4Mediators of inflammation · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lin LuoSchool of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China.
Xianzhen HuDepartment of Neurosurgery, University of Alabama at Birmingham, 1600 6th Avenue South, CHB 118A, Birmingham, AL, 35233, USA.
Michael L DixonDepartment of Neurosurgery, University of Alabama at Birmingham, 1600 6th Avenue South, CHB 118A, Birmingham, AL, 35233, USA.
Brandon J PopeNIH Medical Scientist Training Program, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jonathan D LeavenworthDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Chander RamanDepartment of Dermatology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
William R MeadorDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jianmei W LeavenworthDepartment of Neurosurgery, University of Alabama at Birmingham, 1600 6th Avenue South, CHB 118A, Birmingham, AL, 35233, USA. jleavenworth@uabmc.edu.ORCID http://orcid.org/0000-0002-4100-9883
University of Alabama at Birmingham · USNantong University · CN

Funding

IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
Contribution of the effector Treg-B-antibody nexus to the regulation of CNS autoimmunityR01AI148711 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEAVENWORTH, JIANMEI WU · 2020 to 2024
$2.2M
NIAID NIH HHS R01 AI148711NIAID NIH HHS T32 AI007051NIH HHS R01AI148711University of Alabama at Birmingham Faculty Start-up fundsU.S. Department of Defense W81XWH-18-1-0315
6 · The paper itself

Abstract

backgroundFollicular regulatory T (T

methodsTo determine the impact of dysregulated regulatory T cells (Tregs), T

resultsMice with a FoxP3-specific deletion of Blimp1 developed severe EAE and failed to recover compared to control mice, reflecting conversion of Tregs into interleukin (IL)-17A/granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing effector T cells associated with increased T

conclusionsBlimp1 is essential for the maintenance of T

Indexed as

AnimalsAntibody FormationAutoimmunityCell DifferentiationEncephalomyelitis, Autoimmune, ExperimentalGerminal CenterMiceMice, Inbred C57BLPositive Regulatory Domain I-Binding Factor 1T-Lymphocytes, RegulatoryPositive Regulatory Domain I-Binding Factor 1Prdm1 protein, mouseCNS autoimmunityExperimental autoimmune encephalomyelitisFollicular regulatory T cellsHumoral antibody responseMultiple sclerosisTreg lineage stability

Identifiers

PMID33468194
PMCPMC7814531
OpenAlexW3124048762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.