ArticleMicrobial cell factories2021
Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin.
Article in Microbial cell factories, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 83 citations in OpenAlex.
- Enzyme-catalysed synthesis of pyridines from biomass-derived feedstocks.Organic & biomolecular chemistry · 2026Article
- Recombinant Protein Expression in Rhodococcus species.Current protocols · 2026Article
- Engineering a robust and autonomous biological funneling for efficient valorization of lignin-related aromatics.Nature communications · 2026Article
- From Biocontrol to Synthesis: Innovative Progress ofInternational journal of molecular sciences · 2025Review
- Scaling-up the Bioconversion of Lignin to 2,4-Pyridinedicarboxylic Acid With Engineered Pseudomonas putida for Bio-Based Plastics Production.Biotechnology and bioengineering · 2025Article
- Lignin-Degrading Enzymes and the Potential ofMicroorganisms · 2025Review
- Kraft lignin decomposition by lignin-derived aromatic compound degrader Rhodococcus sp. DK17.World journal of microbiology & biotechnology · 2025Article
- Identification, Characterization, and Ultrastructure Analysis of the Phenol-DegradingMicroorganisms · 2024Article
- Hydroxycinnamic Acid Extraction from Multiple Lignocellulosic Sources: Correlations with Substrate Composition and Taxonomy for Flavoring and Antioxidant Applications.Journal of agricultural and food chemistry · 2024Article
- A mycofactocin-associated dehydrogenase is essential for ethylene glycol metabolism by Rhodococcus jostii RHA1.Applied microbiology and biotechnology · 2024Article
- Metabolic engineering ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Benzenoid Aromatics from Renewable Resources.Chemical reviews · 2024Review
- Enterobacter spp. isolates from an underground coal mine reveal ligninolytic activity.BMC microbiology · 2024Article
- Blue valorization of lignin-derived monomers via reprogramming marine bacteriumApplied and environmental microbiology · 2024Article
- The chemical logic of enzymatic lignin degradation.Chemical communications (Cambridge, England) · 2024Review
- Bacterial transformation of lignin: key enzymes and high-value products.Biotechnology for biofuels and bioproducts · 2024Review
- Microbial Upcycling of Depolymerized Lignin into Value-Added Chemicals.Biodesign research · 2024Article
- Lignin conversion to β-ketoadipic acid byScience advances · 2023Article
- Engineering ofHeliyon · 2023Article
- Engineering a Carboxyl Methyltransferase for the Formation of a Furan-Based Bioplastic Precursor.ChemSusChem · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Genetic modification of Rhodococcus jostii RHA1 was carried out in order to optimise the production of pyridine-2,4-dicarboxylic acid and pyridine-2,5-dicarboxylic acid bioproducts from lignin or lignocellulose breakdown, via insertion of either the Sphingobium SYK-6 ligAB genes or Paenibacillus praA gene respectively. Insertion of inducible plasmid pTipQC2 expression vector containing either ligAB or praA genes into a ΔpcaHG R. jostii RHA1 gene deletion strain gave 2-threefold higher titres of PDCA production from lignocellulose (200-287 mg/L), compared to plasmid expression in wild-type R. jostii RHA1. The ligAB genes were inserted in place of the chromosomal pcaHG genes encoding protocatechuate 3,4-dioxygenase, under the control of inducible P
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