Evidence map›Paper›PMID 33468089›Full record

ArticleBMC public health2021

Barriers to using HIV pre-exposure prophylaxis (PrEP) and sexual behaviour after stopping PrEP: a cross-sectional study in Germany.

Uwe Koppe, Ulrich Marcus, Stefan Albrecht, Klaus Jansen, Heiko Jessen, Barbara Gunsenheimer-Bartmeyer, Viviane Bremer

Open access · goldAbstract read
In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  13. Perceptions and Acceptability of Doxycycline-Based STI Prophylaxis: Insights from Consumers and Healthcare Providers in Queensland.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Uwe KoppeDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany. koppeu@rki.de.ORCID 0000-0001-9718-5811
Ulrich MarcusDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Stefan AlbrechtDepartment of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
Klaus JansenDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Heiko JessenPraxis Jessen2 und Kollegen, Berlin, Germany.
Barbara Gunsenheimer-BartmeyerDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Viviane BremerDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Robert Koch Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPersistence of individuals at risk of HIV with Pre-Exposure Prophylaxis (PrEP) is critical for its impact on the HIV epidemic. We analysed factors associated with stopping PrEP, barriers that may deter people from continuing PrEP and investigated sexual behaviour after stopping PrEP.

methodsCurrent and former PrEP users in Germany were recruited to complete an anonymous online survey on PrEP use and sexual behaviour. Participants were recruited through dating apps, a PrEP community website, anonymous testing sites and peers. The results were analysed using descriptive methods and logistic regression.

resultsWe recruited 4848 current and 609 former PrEP users in two study waves (July-October 2018, April-June 2019). Former PrEP users were more likely 18-29 years old than current users (adjusted OR = 1.6, 95% confidence interval (CI) 1.1-2.3). Moreover, they were more often unhappy with their sex life, which was more pronounced in former daily PrEP users (aOR = 4.5, 95% CI 2.9-7.1) compared to former on-demand users (aOR = 1.8, 95% CI 1.1-2.9, p

conclusionsTo maximise persistence with PrEP we need to develop strategies for younger PrEP users, reduce logistic barriers to access PrEP, and to develop effective communication on side-effect management. Moreover, prevention strategies for people stopping PrEP are required, since some remain at high risk for HIV.

Indexed as

HIV InfectionsPre-Exposure ProphylaxisAdolescentAdultCross-Sectional StudiesGermanyHomosexuality, MaleHumansMaleSexual BehaviorYoung AdultCondom useFormer useHIV pre-exposure prophylaxisMenSide effectsWho have sex with men

Identifiers

PMID33468089
PMCPMC7816315
OpenAlexW3122999266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.