ArticleProceedings. Biological sciences2021
Aminopeptidase-N modulation assists lean mass anabolism during refuelling in the white-throated sparrow.
Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Divergent migratory strategies lead to variable refueling performance amongst Gray Catbirds (Dumetella carolinensis) during spring stopover in the Gulf of Mexico.Movement ecology · 2025Article
- Long-duration wind tunnel flights reveal exponential declines in protein catabolism over time in short- and long-distance migratory warblers.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Migratory disposition alters lean mass dynamics and protein metabolism in migratory white-throated sparrows (American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Songbirds meet the extreme metabolic demands of migration by burning both stored fat and protein. However, catabolizing these endogenous tissues for energy leads to organ atrophy, and reductions in gastrointestinal tissue can be as great as 50% of the pre-flight mass. Remarkably, during stopover refuelling birds quickly regain digestive mass and performance. Aminopeptidase-N (APN) is a brush-border enzyme responsible for late-stage protein digestion and may critically assist tissue reconstruction during the stopover, thus compensating for reduced gut size. We hypothesized that birds recovering from a fast would differentially upregulate APN activity relative to disaccharidases to rapidly process and assimilate dietary protein into lean mass. We fasted 23 wild-caught migratory white-throated sparrows (
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