Evidence map›Paper›PMID 33468010›Full record

ArticleProceedings. Biological sciences2021

Supplemented nutrition decreases helminth burden and increases drug efficacy in a natural host-helminth system.

Amy R Sweeny, Melanie Clerc, Paulina A Pontifes, Saudamini Venkatesan, Simon A Babayan, Amy B Pedersen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Glycyrrhiza polysaccharide attenuatesFrontiers in veterinary science · 2025
    Article
  7. Divergent age-related changes in parasite infection occur independently of behaviour and demography in a wild ungulate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The genome sequence of the wood mouse,Wellcome open research · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Amy R SweenyInstitute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
Melanie ClercMRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Paulina A PontifesDepartamento de Etología, Fauna Silvestre y Animales de Laboratorio, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Avenida Ciudad Universitaria 3000, CP 04510 Coyoacán, Ciudad de México, México.
Saudamini VenkatesanInstitute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
Simon A BabayanInstitute of Biodiversity Animal Health and Comparative Medicine, University of Glasgow, Glasgow G12 8QQ, UK.
Amy B PedersenInstitute of Evolutionary Biology and Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
Centre for Immunity, Infection and Evolution · GBCentre for Inflammation Research · GBUniversidad Nacional Autónoma de México · MXUniversity of Glasgow · GB

Funding

Wellcome TrustWellcome Trust 095831Wellcome Trust 097821/Z/11/ZWellcome Trust J22737
6 · The paper itself

Abstract

Gastrointestinal (GI) helminths are common parasites of humans, wildlife, and livestock, causing chronic infections. In humans and wildlife, poor nutrition or limited resources can compromise an individual's immune response, predisposing them to higher helminth burdens. This relationship has been tested in laboratory models by investigating infection outcomes following reductions of specific nutrients. However, much less is known about how diet supplementation can impact susceptibility to infection, acquisition of immunity, and drug efficacy in natural host-helminth systems. We experimentally supplemented the diet of wood mice (

Indexed as

Nematospiroides dubiusPharmaceutical PreparationsAnimalsDietary SupplementsHost-Parasite InteractionsMiceMurinaePharmaceutical Preparationsanthelmintic treatmentApodemus sylvaticusgastrointestinal helminthsHeligmosomoides polygyrushost–parasite interactionsnutrition

Identifiers

PMID33468010
PMCPMC7893286
OpenAlexW3124727079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.