Evidence map›Paper›PMID 33467982›Full record

ArticleEmerging microbes & infections2021

Saliva viral load better correlates with clinical and immunological profiles in children with coronavirus disease 2019.

Gilbert T Chua, Joshua S C Wong, Kelvin K W To, Ivan C S Lam, Felix Y S Yau, Wai Hung Chan, Polly P K Ho, Jaime S R Duque, Cyril C Y Yip, Anthony C K Ng and 12 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Comparing SARS-CoV-2 Viral Load in Human Saliva to Oropharyngeal Swabs, Nasopharyngeal Swabs, and Sputum: A Systematic Review and Meta-Analysis.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023
    Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Gilbert T ChuaDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0003-0333-0059
Joshua S C WongPaediatric Infectious Disease Unit, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0003-4815-5821
Kelvin K W ToDepartment of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-1921-5824
Ivan C S LamPaediatric Infectious Disease Unit, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-6909-2754
Felix Y S YauDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-5471-9139
Wai Hung ChanDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-9256-4799
Polly P K HoDepartment of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0001-7836-5243
Jaime S R DuqueDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-5292-5510
Cyril C Y YipDepartment of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Anthony C K NgDepartment of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.
Wilfred H S WongDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0001-8396-2368
Joyce H Y KwongHaematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
Kate F S LeungHaematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
P T WanHaematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
Kelly LamHaematology laboratory, Department of Pathology, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.
Ian C K WongCentre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0001-8242-0014
Janette KwokDivison of Transplantation and Immunogenetics, Department of Pathology, Queen Mary Hospital, HKSAR, People's Republic of China.ORCID https://orcid.org/0000-0003-0038-1897
Marco H K HoDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0003-1802-2120
Godfrey C F ChanDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0001-5032-8985
Yu Lung LauDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-4780-0289
Patrick IpDepartment of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-6797-6898
Mike Y W KwanPaediatric Infectious Disease Unit, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, People's Republic of China.ORCID https://orcid.org/0000-0002-1476-9625

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric COVID-19 studies exploring the relationships between NPS and saliva viral loads, clinical and immunological profiles are lacking.

methodsDemographics, immunological profiles, nasopharyngeal swab (NPS), and saliva samples collected on admission, and hospital length of stay (LOS) were assessed in children below 18 years with COVID-19.

findings91 patients were included between March and August 20 20. NPS and saliva viral loads were correlated (

interpretationSaliva viral loads on admission in children correlated better with clinical and immunological profiles than NPS.

Indexed as

Viral LoadAdolescentChildChild, PreschoolCOVID-19FemaleHumansLymphocyte CountMaleNasopharynxSalivaSARS-CoV-2childrenCOVID-19immunological profilessalivaviral load

Identifiers

PMID33467982
PMCPMC7899683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.