Evidence map›Paper›PMID 33467745›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinson's Disease.

Federica Rey, Sara Ottolenghi, Toniella Giallongo, Alice Balsari, Carla Martinelli, Robert Rey, Raffaele Allevi, Anna Maria Di Giulio, Gian Vincenzo Zuccotti, Serena Mazzucchelli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Recent Advances in Molecular Research on Hydrogen Sulfide (HInternational journal of molecular sciences · 2022
    Pooled it
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  4. Mechanisms Underlying Altitude-Induced and Group 3 Pulmonary Hypertension.International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Federica ReyLaboratory of Pharmacology, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.ORCID 0000-0001-7944-3143
Sara OttolenghiLaboratory of Biochemistry, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.ORCID 0000-0003-2988-0593
Toniella GiallongoLaboratory of Pharmacology, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.
Alice BalsariLaboratory of Pharmacology, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.
Carla MartinelliLaboratory of Pathological Anatomy, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.ORCID 0000-0002-3376-7705
Robert ReyLaboratory of Pathological Anatomy, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.
Raffaele AlleviPediatric Clinical Research Center Fondazione "Romeo ed Enrica Invernizzi", Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.
Anna Maria Di GiulioLaboratory of Pharmacology, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.
Gian Vincenzo ZuccottiPediatric Clinical Research Center Fondazione "Romeo ed Enrica Invernizzi", Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0002-2795-9874
Serena MazzucchelliPediatric Clinical Research Center Fondazione "Romeo ed Enrica Invernizzi", Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy.ORCID 0000-0001-6904-8895
Roberta ForestiUniversity Paris Est Creteil, INSERM, IMRB, F-94010 Créteil, France.
Michele SamajaLaboratory of Biochemistry, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.ORCID 0000-0002-0705-340X
Stephana CarelliLaboratory of Pharmacology, Department of Health Sciences, University of Milan, Via Antonio di Rudinì 8, 20142 Milano, Italy.ORCID 0000-0003-4603-396X
University of Milan · ITInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Existing therapies for Parkinson's disease (PD) are only symptomatic. As erythropoietin (EPO) is emerging for its benefits in neurodegenerative diseases, here, we test the protective effect driven by EPO in in vitro (SH-SY5Y cells challenged by MPP

Indexed as

erythropoietin (EPO)mitochondrial metabolismneuroprotectionParkinson’s diseaseredox imbalancetyrosine hydroxylase (TH)

Identifiers

PMID33467745
PMCPMC7830512
OpenAlexW3120987125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.