ArticleNanomaterials (Basel, Switzerland)2021
Polyglycerol Ester-Based Low Energy Nanoemulsions with Red Raspberry Seed Oil and Fruit Extracts: Formulation Development toward Effective In Vitro/In Vivo Bioperformance.
Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Targeted delivery of PTX by lactoferrin-modified nanoemulsions for the treatment of glioblastoma.International journal of pharmaceutics: X · 2025Article
- Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes.Materials today. Bio · 2025Review
- Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels.Pharmaceutics · 2025Article
- Aqueous Solutions of Oil-Soluble Polyglycerol Esters: Structuring and Emulsifying Abilities.Molecules (Basel, Switzerland) · 2025Article
- Recent Advances in the Properties and Applications of Polyglycerol Fatty Acid Esters.Polymers · 2025Review
- Optimization, In Vitro and Ex Vivo Assessment of Nanotransferosome Gels Infused with a Methanolic Extract ofGels (Basel, Switzerland) · 2024Article
- Review
- Nutritionally Important Pro-Health Active Ingredients and Antioxidant Properties of Fruits and Fruit Juice of Selected Biennial FruitingPharmaceuticals (Basel, Switzerland) · 2023Article
- Molluscicidal and Cercaricidal Effects ofMolecules (Basel, Switzerland) · 2023Article
- The In Vitro, Ex Vivo, and In Vivo Effect of Edible Oils: A Review on Cell Interactions.Pharmaceutics · 2023Review
- Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts.International journal of molecular sciences · 2022Article
- Red Raspberry Seed Oil Low Energy Nanoemulsions: Influence of Surfactants, Antioxidants, and Temperature on Oxidative Stability.Antioxidants (Basel, Switzerland) · 2022Article
- Development of microemulsion containing thai herbal remedy extract for treatment of urticaria.Journal of advanced pharmaceutical technology & researchArticle
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Authors and funding
11 authors.
Funding
Abstract
This study focuses on the development of biocompatible oil-in-water (O/W) nanoemulsions based on polyglycerol esters, as promising carriers for natural actives: red raspberry seed oil-RO and hydro-glycolic fruit extracts from red raspberry-RE and French oak-FE. Nanoemulsions were obtained via phase inversion composition (PIC) method at room temperature by dilution of microemulsion phase, confirmed by visual appearance, percentage of transmittance, microscopic, rheological and Differential Scanning Calorimetry (DSC) investigations. The results have shown that the basic RO-loaded formulation could be further enriched with hydro-glycolic fruit extracts from red raspberry or French oak, while keeping a semi-transparent appearance due to the fine droplet size (Z-ave: 50 to 70 nm, PDI value ≤ 0.1). The highest antioxidant activity (~92% inhibition of the DPPH radical) was achieved in the formulation containing both lipophilic (RO) and hydrophilic antioxidants (FE), due to their synergistic effect. The nanoemulsion carrier significantly increased the selective cytotoxic effect of RO towards malignant melanoma (Fem-X) cells, compared to normal human keratinocytes (HaCaT). In vivo study on human volunteers showed satisfactory safety profiles and significant improvement in skin hydration during 2 h after application for all nanoemulsions. Therefore, polyglycerol ester-based nanoemulsions can be promoted as effective carriers for red raspberry seed oil and/or hydro-glycolic fruit extracts in topical formulations intended for skin protection and hydration.
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