Evidence map›Paper›PMID 33467681›Full record

ReviewInternational journal of molecular sciences2021

Targeting WASF3 Signaling in Metastatic Cancer.

Reid Loveless, Yong Teng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. PSIP1 promotes gefitinib resistance in lung adenocarcinoma by inducing the expression of WASF3 and its downstream ITGB3/AKT signaling.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. ATAD3A: A Key Regulator of Mitochondria-Associated Diseases.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. MiRNA-93: a novel signature in human disorders and drug resistance.Cell communication and signaling : CCS · 2023
    Review
  11. Article
  12. The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Reid LovelessDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-2237-7442
Yong TengDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-1856-7289
Augusta University · US

Funding

ATAD3A as a Novel Target in Head and Neck CancerR01DE028351 · NIDCR · EMORY UNIVERSITY · PI TENG, YONG · 2019 to 2023
$1.9M
The Impact of Arf1 on Hypoxia Signaling and Oral CancerR03DE028387 · NIDCR · EMORY UNIVERSITY · PI TENG, YONG · 2019 to 2020
$306k
NIDCR NIH HHS R01 DE028351NIDCR NIH HHS R01DE028351NIDCR NIH HHS R03 DE028387NIDCR NIH HHS R03DE028387
6 · The paper itself

Abstract

Increasing evidence indicates that cancer metastasis is regulated by specific genetic pathways independent of those controlling tumorigenesis and cancer growth. WASF3, a Wiskott-Aldrich syndrome protein family member, appears to play a major role not only in the regulation of actin cytoskeleton dynamics but also in cancer cell invasion/metastasis. Recent studies have highlighted that WASF3 is a master regulator and acts as a pivotal scaffolding protein, bringing the various components of metastatic signaling complexes together both spatially and temporally. Herein, targeting WASF3 at the levels of transcription, protein stability, and phosphorylation holds great promise for metastasis suppression, regardless of the diverse genetic backgrounds associated with tumor development. This review focuses on the critical and distinct contributions of WASF3 in the regulation of signal pathways promoting cancer cell invasion and metastasis.

Indexed as

Gene Expression Regulation, NeoplasticNeoplasm MetastasisAnimalsATPases Associated with Diverse Cellular ActivitiesCell MovementEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSP70 Heat-Shock ProteinsHumansHypoxia-Inducible Factor 1, alpha SubunitJanus Kinase 2Membrane ProteinsMiceMicroRNAsMitochondrial ProteinsNeoplasm InvasivenessATAD3A protein, humanATPases Associated with Diverse Cellular ActivitiesEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHIF1A protein, humanHSP70 Heat-Shock ProteinsHypoxia-Inducible Factor 1, alpha SubunitJAK2 protein, humanJanus Kinase 2Membrane ProteinsMicroRNAsMitochondrial ProteinsPhosphatidylinositol 3-KinasesSTAT3 protein, humanSTAT3 Transcription FactorWASF3 protein, humanWasf3 protein, mouseWiskott-Aldrich Syndrome Protein Familycancerdrug targetmetastasissignaling networkWASF3

Identifiers

PMID33467681
PMCPMC7830529
OpenAlexW3118936295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.