Evidence map›Paper›PMID 33467666›Full record

ArticleJournal of clinical medicine2021

Impact of Different Positive End-Expiratory Pressures on Lung Mechanics in the Setting of Moderately Elevated Intra-Abdominal Pressure and Acute Lung Injury in a Porcine Model.

Mascha O Fiedler, Emilis Simeliunas, B Luise Deutsch, Dovile Diktanaite, Alexander Harms, Maik Brune, Maximilian Dietrich, Florian Uhle, Markus A Weigand, Armin Kalenka

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mascha O FiedlerDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0002-0127-2783
Emilis SimeliunasDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
B Luise DeutschFaculty of Medicine, Justus Liebig University, 35392 Giessen, Germany.
Dovile DiktanaiteDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Alexander HarmsInstitute of Pathology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Maik BruneDepartment of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Maximilian DietrichDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Florian UhleDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.ORCID 0000-0001-8876-7430
Markus A WeigandDepartment of Anesthesiology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Armin KalenkaTranslational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), 69120 Heidelberg, Germany.ORCID 0000-0003-3394-481X
Heidelberg University · DEJustus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of a moderately elevated intra-abdominal pressure (IAP) on lung mechanics in acute respiratory distress syndrome (ARDS) have still not been fully analyzed. Moreover, the optimal positive end-expiratory pressure (PEEP) in elevated IAP and ARDS is unclear. In this paper, 18 pigs under general anesthesia received a double hit lung injury. After saline lung lavage and 2 h of injurious mechanical ventilation to induce an acute lung injury (ALI), an intra-abdominal balloon was filled until an IAP of 10 mmHg was generated. Animals were randomly assigned to one of three groups (group A = PEEP 5, B = PEEP 10 and C = PEEP 15 cmH

Indexed as

ALIARDSend-expiratory lung volumeintraabdominal pressurePEEPtranspulmonary pressure

Identifiers

PMID33467666
PMCPMC7830768
OpenAlexW3118676157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.