Evidence map›Paper›PMID 33467632›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Extra Virgin Olive Oil Phenolic Extract on Human Hepatic HepG2 and Intestinal Caco-2 Cells: Assessment of the Antioxidant Activity and Intestinal Trans-Epithelial Transport.

Martina Bartolomei, Carlotta Bollati, Maria Bellumori, Lorenzo Cecchi, Ivan Cruz-Chamorro, Guillermo Santos-Sánchez, Giulia Ranaldi, Simonetta Ferruzza, Yula Sambuy, Anna Arnoldi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Seaweed (Journal of agricultural and food chemistry · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Olive (Nutrients · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Martina BartolomeiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-3851-3392
Carlotta BollatiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-5698-1325
Maria BellumoriDepartment of Neuroscience, Psychology, Drug and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Florence, Italy.ORCID 0000-0003-3583-012X
Lorenzo CecchiDepartment of Neuroscience, Psychology, Drug and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Florence, Italy.ORCID 0000-0002-9332-704X
Ivan Cruz-ChamorroDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-6547-8078
Guillermo Santos-SánchezDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0001-5790-2302
Giulia RanaldiCREA, Food and Nutrition Research Centre, 00178 Rome, Italy.
Simonetta FerruzzaCREA, Food and Nutrition Research Centre, 00178 Rome, Italy.ORCID 0000-0002-9609-9927
Yula SambuyCREA, Food and Nutrition Research Centre, 00178 Rome, Italy.ORCID 0000-0003-2522-6279
Anna ArnoldiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.ORCID 0000-0002-0987-3014
Nadia MulinacciDepartment of Neuroscience, Psychology, Drug and Child Health, Pharmaceutical and Nutraceutical Section, University of Florence, 50019 Florence, Italy.
Carmen LammiDepartment of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.
University of Milan · ITUniversity of Florence · IT

Funding

AGER Foundation - Olive Tree and Oil: Competitive - Claims of olive oil to improve the market value of the product 2016-0174
6 · The paper itself

Abstract

In the framework of research aimed at promoting the nutraceutical properties of the phenolic extract (BUO) obtained from an extra virgin olive oil of the Frantoio cultivar cultivated in Tuscany (Italy), with a high total phenols content, this study provides a comprehensive characterization of its antioxidant properties, both in vitro by Trolox equivalent antioxidant capacity, oxygen radical absorbance capacity, ferric reducing antioxidant power, and 2,2-diphenyl-1-picrylhydrazyl assays, and at the cellular level in human hepatic HepG2 and human intestinal Caco-2 cells. Notably, in both cell systems, after H

Indexed as

hydroxytyrosollipid peroxidationoleuropein aglyconephenolic phytocomplexROSsecoiridoidstrans-epithelial transport

Identifiers

PMID33467632
PMCPMC7829860
OpenAlexW3120438996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.