ArticleViruses2021
Obstetric Outcomes of SARS-CoV-2 Infection in Asymptomatic Pregnant Women.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
9.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021Pooled it
- Asymptomatic SARS-CoV-2 infection: A systematic review and meta-analysis.Proceedings of the National Academy of Sciences of the United States of America · 2021Pooled it
- Tuberculosis in Pregnant Women After COVID-19: Features of Prevention, Diagnosis, and Treatment (Narrative Review).Journal of clinical medicine · 2025Review
- Perinatal Outcomes of Newborns of COVID-19-Infected Pregnant Women: An Updated Systematic Review and Meta-Analysis.Cureus · 2024Review
- Neonatal outcomes of maternal prenatal coronavirus infection.Pediatric research · 2024Review
- COVID-19 vaccine hesitancy among pregnant women attending public antenatal clinics in Dar es Salaam, Tanzania.Human vaccines & immunotherapeutics · 2023Article
- SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics.Med (New York, N.Y.) · 2023Article
- Psychiatric disorders during pregnancy in asymptomatic and mildly symptomatic SARS-CoV-2 positive women: Prevalence and effect on outcome.Psychiatry research · 2023Article
- The effect of COVID-19 pandemic on antibiotic usage during pregnancy.Saudi medical journal · 2023Article
- The coronavirus disease 2019 infection in pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis.Obstetrics & gynecology science · 2023Article
- Cross-Sectional Survey of Views on COVID-19 and Its Vaccines Among Pregnant Women.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Symptomatic and Asymptomatic SARS-CoV-2 Infection and Follow-up of Neutralizing Antibody Levels.Biomedical and environmental sciences : BES · 2022Article
- HIV and SARS-CoV-2 Pathogenesis and Vaccine Development.Viruses · 2022Article
- Point: Uncertainty about estimating the risks of COVID-19 during pregnancy.Paediatric and perinatal epidemiology · 2022Article
- Indirect impact of SARS-CoV-2 pandemic on pregnancy and childbirth outcomes: A nine-month long experience from a university center in Lombardy.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022Article
- Impact of COVID-19-Related Lockdown on Delivery and Perinatal Outcomes: A Retrospective Cohort Study.Journal of clinical medicine · 2022Article
- Adverse Perinatal Outcomes in COVID-19 Infected Pregnant Women: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2022Review
- Evidence of possible SARS-CoV-2 vertical transmission according to World Health Organization criteria in asymptomatic pregnant women.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2021Article
- Perinatal outcomes of pregnant women having SARS-CoV-2 infection.Taiwanese journal of obstetrics & gynecology · 2021Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
54 authors at 20 institutions in 1 country.
Monica Cruz-LeminiDepartment of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, 08025 Barcelona, Spain.ORCID 0000-0002-6807-3578
Elena Ferriols PerezDepartment of Gynecology and Obstetrics, Parc de Salut Mar University Hospital, 08003 Barcelona, Spain.ORCID 0000-0002-8003-0335
Maria Luisa de la Cruz ContyFundacion de Investigacion Biomedica, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain.
Africa Caño AguilarDepartment of Gynecology and Obstetrics, San Cecilio University Hospital of Granada, 18016 Granada, Spain.
Maria Begoña Encinas PardillaDepartment of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain.
Pilar Prats RodríguezDepartment of Gynecology and Obstetrics, Dexeus University Hospital, 08028 Barcelona, Spain.ORCID 0000-0001-9216-9118
Marta Muner HernandoDepartment of Gynecology and Obstetrics, La Paz University Hospital, 28046 Madrid, Spain.
Laura Forcen AcebalDepartment of Gynecology and Obstetrics, Doce de Octubre University Hospital, 28041 Madrid, Spain.
Pilar Pintado RecarteDepartment of Gynecology and Obstetrics, Gregorio Marañon University Hospital, 28007 Madrid, Spain.
Maria Del Carmen Medina MallenDepartment of Gynecology and Obstetrics, Women and Perinatal Health Research Group, Biomedical Research Institute (IIB-Sant Pau), Santa Creu i Sant Pau University Hospital, 08025 Barcelona, Spain.ORCID 0000-0002-1219-5947
Noelia Perez PerezDepartment of Gynecology and Obstetrics, San Carlos University Hospital, 28040 Madrid, Spain.
Judit Canet RodriguezDepartment of Gynecology and Obstetrics, Santa Caterina Hospital, 17190 Girona, Spain.
Ana Villalba YarzaDepartment of Gynecology and Obstetrics, University Hospital of Salamanca, 37007 Salamanca, Spain.
Olga Nieto VelascoDepartment of Gynecology and Obstetrics, Quironsalud Madrid University Hospital, 28223 Madrid, Spain.ORCID 0000-0001-8311-9442
Pablo Guillermo Del Barrio FernandezDepartment of Gynecology and Obstetrics, Getafe University Hospital, 28905 Madrid, Spain.
Carmen Maria Orizales LagoDepartment of Gynecology and Obstetrics, Severo Ochoa University Hospital, 28911 Madrid, Spain.
Beatriz Marcos PuigDepartment of Gynecology and Obstetrics, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain.
Begoña Muñoz AbellanaDepartment of Gynecology and Obstetrics, Sant Joan de Reus University Hospital, 43204 Tarragona, Spain.
Laura Fuentes RicoyDepartment of Gynecology and Obstetrics, University Hospital of Ferrol, 15405 A Coruña, Spain.
Agueda Rodriguez VicenteDepartment of Gynecology and Obstetrics, Doctor Josep Trueta University Hospital of Girona, 17007 Girona, Spain.ORCID 0000-0003-0055-8701
Maria Jesus Janeiro FreireDepartment of Gynecology and Obstetrics, University Hospital Complex of A Coruña, 15006 A Coruña, Spain.
Macarena Alferez Alvarez-MalloDepartment of Gynecology and Obstetrics, HM Hospitals, 28015 Madrid, Spain.
Cristina Casanova PedrazDepartment of Gynecology and Obstetrics, University Hospital of Torrejon, 28850 Madrid, Spain.
Onofre Alomar MateuDepartment of Gynecology and Obstetrics, Regional Hospital of Inca, 07300 Illes Balears, Spain.
Cristina Lesmes HerediaDepartment of Gynecology and Obstetrics, Parc Taulí Hospital, 08208 Barcelona, Spain.
Juan Carlos Wizner de AlvaDepartment of Gynecology and Obstetrics, San Pedro de Alcántara Hospital, 10003 Cáceres, Spain.ORCID 0000-0001-6390-1381
Alma Posadas San JuanDepartment of Gynecology and Obstetrics, Rio Hortega University Hospital, 47012 Valladolid, Spain.
Montserrat Macia BadiaDepartment of Gynecology and Obstetrics, Arnau de Vilanova University Hospital, 25198 Lleida, Spain.
Cristina Alvarez ColomoDepartment of Gynecology and Obstetrics, Valladolid University Clinical Hospital, 47003 Valladolid, Spain.
Antonio Sanchez MuñozDepartment of Gynecology and Obstetrics, General University Hospital of Ciudad Real, 13005 Ciudad Real, Spain.
Laia Pratcorona AlicartDepartment of Gynecology and Obstetrics, Germans Trias i Pujol University Hospital, 08916 Barcelona, Spain.
Ruben Alonso SaizDepartment of Gynecology and Obstetrics, University Hospital of Burgos, 09006 Burgos, Spain.
Monica Lopez RodriguezDepartment of Gynecology and Obstetrics, Joan XXIII University Hospital of Tarragona, 43005 Tarragona, Spain.
Maria Carmen Barbancho LopezDepartment of Gynecology and Obstetrics, Infanta Sofia University Hospital, 28703 Madrid, Spain.
Marta Ruth Meca CasbasDepartment of Gynecology and Obstetrics, Poniente Hospital of Almeria, 04700 Almeria, Spain.
Oscar Vaquerizo RuizDepartment of Gynecology and Obstetrics, University Hospital of Cabueñes, 33394 Asturias, Spain.
Eva Moran AntolinDepartment of Gynecology and Obstetrics, Son Espases University Hospital, 07120 Illes Balears, Spain.
Maria Jose Nuñez ValeraDepartment of Gynecology and Obstetrics, Virgen de la Luz Hospital, 16002 Cuenca, Spain.
Camino Fernandez FernandezDepartment of Gynecology and Obstetrics, University Assistance Complex of Leon, 24001 Leon, Spain.
Albert Tubau NavarraDepartment of Gynecology and Obstetrics, Son Llatzer University Hospital, 07198 Illes Balears, Spain.ORCID 0000-0001-5460-0763
Alejandra Maria Cano GarciaDepartment of Gynecology and Obstetrics, University Hospital of El Tajo, 28300 Madrid, Spain.
Susana Soldevilla PerezDepartment of Gynecology and Obstetrics, University Hospital of Jerez de la Frontera, 11407 Cadiz, Spain.
Irene Gattaca AbasoloDepartment of Gynecology and Obstetrics, Txagorritxu University Hospital of Araba, 01009 Araba, Spain.
Jose Adanez GarciaDepartment of Gynecology and Obstetrics, Central University Hospital of Asturias, 33011 Asturias, Spain.
Alberto Puertas PrietoDepartment of Gynecology and Obstetrics, Virgen de las Nieves University Hospital, 18014 Granada, Spain.
Rosa Ostos SernaDepartment of Gynecology and Obstetrics, Virgen de Valme University Hospital, 41014 Sevilla, Spain.
Maria Del Pilar Guadix MartinDepartment of Gynecology and Obstetrics, Virgen Macarena University Hospital, 41009 Sevilla, Spain.
Monica Catalina CoelloDepartment of Gynecology and Obstetrics, Virgen de la Concha Hospital, 49022 Zamora, Spain.
Silvia Espuelas MalonDepartment of Gynecology and Obstetrics, Parc de Salut Mar University Hospital, 08003 Barcelona, Spain.
Jose Antonio Sainz BuenoDepartment of Gynecology and Obstetrics, G. Chacon (Viamed Santa Angela de la Cruz Hospital), 41014 Sevilla, Spain.
Maria Reyes Granell EscobarDepartment of Gynecology and Obstetrics, Juan Ramon Jimenez University Hospital, 21005 Huelva, Spain.ORCID 0000-0002-7553-1688
Sara Cruz MelguizoDepartment of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain.
Oscar Martinez PerezDepartment of Gynecology and Obstetrics, Puerta de Hierro University Hospital of Majadahonda, 28222 Madrid, Spain.ORCID 0000-0002-1457-3446
On Behalf Of The Spanish Obstetric Emergency Group
Hospital Universitario Puerta de Hierro Majadahonda · ESHospital de Sant Pau · ESParc de Salut · ESUniversidade da Coruña · ESCorporació Sanitària Parc Taulí · ESHM Hospitales · ESHospital Clínico San Carlos · ESHospital Comarcal de Inca · ESHospital de Poniente · ESHospital General Universitario de Ciudad Real · ESHospital General Universitario Gregorio Marañón · ESHospital Jerez Puerta del Sur · ESHospital Juan Ramón Jiménez · ESHospital San Juan de la Cruz · ESHospital San Pedro de Alcántara · ESHospital Santa Caterina · ESHospital Son Llatzer · ESHospital Txagorritxu · ESHospital Universitari Arnau de Vilanova · ESHospital Universitari de Girona Doctor Josep Trueta · ES
Funding
Instituto de Salud Carlos III Grant COV20/00021
Abstract
Around two percent of asymptomatic women in labor test positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Spain. Families and care providers face childbirth with uncertainty. We determined if SARS-CoV-2 infection at delivery among asymptomatic mothers had different obstetric outcomes compared to negative patients. This was a multicenter prospective study based on universal antenatal screening for SARS-CoV-2 infection. A total of 42 hospitals tested women admitted for delivery using polymerase chain reaction, from March to May 2020. We included positive mothers and a sample of negative mothers asymptomatic throughout the antenatal period, with 6-week postpartum follow-up. Association between SARS-CoV-2 and obstetric outcomes was evaluated by multivariate logistic regression analyses. In total, 174 asymptomatic SARS-CoV-2 positive pregnancies were compared with 430 asymptomatic negative pregnancies. No differences were observed between both groups in key maternal and neonatal outcomes at delivery and follow-up, with the exception of prelabor rupture of membranes at term (adjusted odds ratio 1.88, 95% confidence interval 1.13-3.11;
Indexed as
AdolescentAdultAsymptomatic InfectionsCOVID-19FemaleHumansInfant, NewbornMiddle AgedMultivariate AnalysisPregnancyPregnancy Complications, InfectiousPregnancy OutcomePregnant PeopleProspective StudiesSARS-CoV-2Spainasymptomatic infectioncoronavirusdeliverymaternal complicationsperinatal outcomespregnancySARS-CoV-2
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