Evidence map›Paper›PMID 33467588›Full record

ArticleToxins2021

Switching Shiga Toxin (Stx) Type from Stx2d to Stx2a but Not Stx2c Alters Virulence of Stx-Producing

Beth A McNichol, Rebecca A Bova, Kieron Torres, Lan N Preston, Angela R Melton-Celsa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Shiga Toxin-ProducingMicroorganisms · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Beth A McNicholHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Rebecca A BovaGeneva Foundation, Tacoma, WA 98402, USA.ORCID 0000-0002-7334-7211
Kieron TorresHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Lan N PrestonMultidrug-Resistant Organism Repository & Surveillance Network, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Angela R Melton-CelsaDepartment of Microbiology & Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
Henry M. Jackson Foundation · USUniformed Services University of the Health Sciences · USWalter Reed Army Institute of Research · US

Funding

Pathogenicity of Shiga Toxin Producing E.coliR37AI020148 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI O'BRIEN, ALISON DAVIS · 2008 to 2016
$3.8M
SHIGA-LIKE TOXIN OF ESCHERICHIA COLIR01AI020148 · NIAID · U.S. UNIFORMED SERVICES UNIV OF HLTH SCI · PI MELTON-CELSA, ANGELA · 1987 to 2017
$3.3M
NIAID NIH HHS R01 AI020148NIH HHS R37 AI020148
6 · The paper itself

Abstract

Shiga toxin (Stx)-producing

Indexed as

Administration, OralAmino Acid SequenceAnimalsChlorocebus aethiopsEscherichia coli InfectionsFecesIntestinesMiceMice, Inbred BALB CShiga-Toxigenic Escherichia coliShiga Toxin 2Survival RateVero CellsVirulenceShiga Toxin 2B2F1Shiga toxin (Stx)Shiga toxin type 2c (Stx2c)Shiga toxin type 2d (Stx2d)STEC

Identifiers

PMID33467588
PMCPMC7829771
OpenAlexW3122799280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.