ArticleAntioxidants (Basel, Switzerland)2021
Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Urinary oxidative stress biomarkers are associated with preterm birth: an Environmental Influences on Child Health Outcomes program study.American journal of obstetrics and gynecology · 2023Pooled it
- Associations of co-exposure to metals and polycyclic aromatic hydrocarbons with aging biomarkers: insights from epidemiology and network toxicology.Frontiers in public health · 2026Article
- Associations of Blood and Urinary Heavy Metals with Stress Urinary Incontinence Risk Among Adults in NHANES, 2003-2018.Biological trace element research · 2025Article
- Exposure to a mixture of four metals and associations with urinary oxidative stress biomarkers in Uruguayan adolescents.Journal of environmental exposure assessment · 2025Article
- Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico.The Science of the total environment · 2024Article
- Associations between oxidative stress biomarkers during pregnancy and infant cognition at 7.5 months.Developmental psychobiology · 2024Article
- Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy.International journal of molecular sciences · 2022Article
- Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.Environmental research · 2021Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
Metal exposure has been associated with a wide range of adverse birth outcomes and oxidative stress is a leading hypothesis of the mechanism of action of metal toxicity. We assessed the relationship between maternal exposure to essential and non-essential metals and metalloids in pregnancy and oxidative stress markers, and sought to identify windows of vulnerability and effect modification by fetal sex. In our analysis of 215 women from the PROTECT birth cohort study, we measured 14 essential and non-essential metals in urine samples at three time points during pregnancy. The oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α) and its metabolite 2,3-dinor-5,6-dihydro-15-15-F2t-IsoP, as well as prostaglandin F2α (PGF2α), were also measured in the same urine samples. Using linear mixed models, we examined the main effects of metals on markers of oxidative stress as well as the visit-specific and fetal sex-specific effects. After adjustment for covariates, we found that a few urinary metal concentrations, most notably cesium (Cs) and copper (Cu), were associated with higher 8-iso-PGF2α with effect estimates ranging from 7.3 to 14.9% for each interquartile range, increase in the metal concentration. The effect estimates were generally in the same direction at the three visits and a few were significant only among women carrying a male fetus. Our data show that higher urinary metal concentrations were associated with elevated biomarkers of oxidative stress. Our results also indicate a potential vulnerability of women carrying a male fetus.
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