ArticleBiomedicines2021
An In-Vitro Analysis of Peri-Implant Mucosal Seal Following Photofunctionalization of Zirconia Abutment Materials.
Article in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The surface-agnostic advantage for peri-implant health: UV photofunctionalization as a positive-sum strategy for biofilm suppression and soft-tissue barrier-a systematic review with qualitative synthesis.International journal of implant dentistry · 2026Pooled it
- Three dimensional (3D) gingival models in periodontal research: a systematic review.Journal of materials science. Materials in medicine · 2023Pooled it
- The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026Review
- Evaluation of Implant Abutment-Soft Tissue Attachment Using 3D Tissue-Engineered Oral Mucosa: A Systematic Review.International journal of dentistry · 2026Review
- Effects of Different Surface Treatments and Accelerated Aging on Dental Zirconia-An In Vitro Study.Journal of functional biomaterials · 2025Article
- Attachment of Human Epithelial Cells to an Anodized Titanium Surface.Materials (Basel, Switzerland) · 2025Article
- Surface modification strategies to reinforce the soft tissue seal at transmucosal region of dental implants.Bioactive materials · 2024Review
- Bioengineering the Junctional Epithelium in 3D Oral Mucosa Models.Journal of functional biomaterials · 2024Review
- Enhancement of Biocompatibility of High-Transparency Zirconia Abutments with Human Gingival Fibroblasts via Cold Atmospheric Plasma Treatment: An In Vitro Study.Journal of functional biomaterials · 2024Article
- Beyond microroughness: novel approaches to navigate osteoblast activity on implant surfaces.International journal of implant dentistry · 2024Review
- Article
- The integration of peri-implant soft tissues around zirconia abutments: Challenges and strategies.Bioactive materials · 2023Review
- Contour Analysis of Three-Dimensional Peri-Implant Mucosal Model as an Endpoint Analysis of Photofunctionalization Effects on Implant Abutment Materials.Materials (Basel, Switzerland) · 2023Article
- Decomposing Organic Molecules on Titanium with Vacuum Ultraviolet Light for Effective and Rapid Photofunctionalization.Journal of functional biomaterials · 2022Article
- Effects of Excimer Laser Treatment of Zirconia Disks on the Adhesion of L929 Fibroblasts.Materials (Basel, Switzerland) · 2022Article
- Clinical Applications of Photofunctionalization on Dental Implant Surfaces: A Narrative Review.Journal of clinical medicine · 2022Review
- The Effect of UV Treatment on Surface Contact Angle, Fibroblast Cytotoxicity, and Proliferation with Two Types of Zirconia-Based Ceramics.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The presence of epithelial and connective tissue attachment at the peri-implant-soft tissue region has been demonstrated to provide a biological barrier of the alveolar bone from the oral environment. This barrier can be improved via surface modification of implant abutment materials. The effect of photofunctionalization on creating a bioactive surface for the enhancement of the epithelial and connective tissue attachment of zirconia implant abutment's peri-implant mucosal interface using organotypic model has not been investigated. Therefore, this study aimed to evaluate the soft tissue seal around peri-implant mucosa and to understand the effect of photofunctionalization on the abutment materials. Three types of abutment materials were used in this study; yttria-stabilized zirconia (YSZ), alumina-toughened zirconia, and grade 2 commercially pure titanium (CPTi) which were divided into nontreated (N-Tx) and photofunctionalized group (UV-Tx). The three-dimensional peri-implant mucosal model was constructed using primary human gingival keratinocytes and fibroblasts co-cultured on the acellular dermal membrane. The biological seal was determined through the concentration of tritiated water permeating the material-soft tissue interface. The biological seal formed by the soft tissue in the N-Tx group was significantly reduced compared to the UV-treated group (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.