Evidence map›Paper›PMID 33467180›Full record

ArticleNutrients2021

Maternal Folic Acid Deficiency Is Associated to Developing Nasal and Palate Malformations in Mice.

Estela Maldonado, Elena Martínez-Sanz, Teresa Partearroyo, Gregorio Varela-Moreiras, Juliana Pérez-Miguelsanz

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. A head start: The relationship of placental factors to craniofacial and brain development.Developmental dynamics : an official publication of the American Association of Anatomists · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Estela MaldonadoDepartamento de Anatomía y Embriología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-1982-6526
Elena Martínez-SanzDepartamento de Anatomía y Embriología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-5492-8459
Teresa PartearroyoDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.ORCID 0000-0002-4401-1233
Gregorio Varela-MoreirasDepartamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanización Montepríncipe, Alcorcón, 28925 Madrid, Spain.ORCID 0000-0001-5158-4999
Juliana Pérez-MiguelsanzDepartamento de Anatomía y Embriología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Universidad Complutense de Madrid · ESUniversidad San Pablo CEU · ES

Funding

DRUGS OF ABUSE &DOPAMINE RELEASE &REUPTAKEK02DA000184 · NIDA · WASHINGTON STATE UNIVERSITY · PI SCHENK, JAMES O · 1993 to 2003
$397k
Banco Santander/Universidad Complutense de Madrid, Spain Complutense Research Group 920202CEU-Banco Santander MCP19V07Ministerio de Ciencia e Innovación-Instituto de Salud Carlos III, Spain PS09/0176Ministerio de Sanidad, Spain PS06/0184
6 · The paper itself

Abstract

Craniofacial development requires extremely fine-tuned developmental coordination of multiple specialized tissues. It has been evidenced that a folate deficiency (vitamin B

Indexed as

Pregnancy, AnimalPregnancy ComplicationsAnimalsCraniofacial AbnormalitiesFemaleFetal DiseasesFolic Acid DeficiencyMaternal Nutritional Physiological PhenomenaMiceMice, Inbred C57BLNasal SeptumNasopharynxPalatePregnancycongenital abnormalitiesmaternal folic acid-deficient dietnasal regionpalate

Identifiers

PMID33467180
PMCPMC7830789
OpenAlexW3124996257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.