ReviewBiomedicines2021
Crosstalk between Depression and Dementia with Resting-State fMRI Studies and Its Relationship with Cognitive Functioning.
Review in Biomedicines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Premorbid de novo artistic creativity in frontotemporal dementia (FTD) syndromes.Journal of neural transmission (Vienna, Austria : 1996) · 2021Pooled it
- Psilocybin in Older Adults: Therapeutic Opportunities in Inflammation-Driven Disorders of Aging-From Depression to Neurodegeneration.International journal of molecular sciences · 2026Review
- Simultaneous PET/fMRI distinguishes the separate and synergistic effects of T2DM and MCI on cerebral glucose metabolism and fALFF.Scientific reports · 2026Article
- Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Altered triple network model connectivity is associated with cognitive function and depressive symptoms in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18.Scientific reports · 2025Article
- Dementia Subtypes Defined Through Neuropsychiatric Symptom-Associated Brain Connectivity Patterns.JAMA network open · 2024Article
- A modified persian version of the self-stigma of depression scale among the Iranian population: a methodological study in 2023.BMC psychology · 2024Article
- Validity and reliability of the Depression Information Needs Scale among the Iranian general population.Frontiers in psychiatry · 2024Article
- Abnormalities in Electroencephalographic Microstates in Patients with Late-Life Depression.Neuropsychiatric disease and treatment · 2024Article
- Aberrant dynamic functional network connectivity in type 2 diabetes mellitus individuals.Cognitive neurodynamics · 2023Article
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Antipsychotics-Induced Changes in Synaptic Architecture and Functional Connectivity: Translational Implications for Treatment Response and Resistance.Biomedicines · 2022Review
- The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer's Disease and Frontotemporal Dementia.Biomedicines · 2022Article
- Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve.Brain sciences · 2022Review
- Major Depression and Onset of Frontotemporal Dementia.Neuropsychiatric disease and treatment · 2022Article
- Functional Neurophysiological Biomarkers of Early-Stage Alzheimer's Disease: A Perspective of Network Hyperexcitability in Disease Progression.Journal of Alzheimer's disease : JAD · 2022Review
- Co-Players in Chronic Pain: Neuroinflammation and the Tryptophan-Kynurenine Metabolic Pathway.Biomedicines · 2021Review
- Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway.Biomedicines · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common type of dementia, and depression is a risk factor for developing AD. Epidemiological studies provide a clinical correlation between late-life depression (LLD) and AD. Depression patients generally remit with no residual symptoms, but LLD patients demonstrate residual cognitive impairment. Due to the lack of effective treatments, understanding how risk factors affect the course of AD is essential to manage AD. Advances in neuroimaging, including resting-state functional MRI (fMRI), have been used to address neural systems that contribute to clinical symptoms and functional changes across various psychiatric disorders. Resting-state fMRI studies have contributed to understanding each of the two diseases, but the link between LLD and AD has not been fully elucidated. This review focuses on three crucial and well-established networks in AD and LLD and discusses the impacts on cognitive decline, clinical symptoms, and prognosis. Three networks are the (1) default mode network, (2) executive control network, and (3) salience network. The multiple properties emphasized here, relevant for the hypothesis of the linkage between LLD and AD, will be further developed by ongoing future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.