Evidence map›Paper›PMID 33467165›Full record

ArticleNutrients2021

Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes.

Melania Melis, Stefano Pintus, Mariano Mastinu, Giovanni Fantola, Roberto Moroni, Marta Yanina Pepino, Iole Tomassini Barbarossa

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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  17. International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Melania MelisDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato (CA), Italy.ORCID 0000-0003-3410-3158
Stefano PintusObesity Surgical Unit ARNAS G. Brotzu, 09121 Cagliari, Italy.
Mariano MastinuDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato (CA), Italy.
Giovanni FantolaObesity Surgical Unit ARNAS G. Brotzu, 09121 Cagliari, Italy.
Roberto MoroniObesity Surgical Unit ARNAS G. Brotzu, 09121 Cagliari, Italy.
Marta Yanina PepinoDepartment of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, Urbana, IL 61801, USA.
Iole Tomassini BarbarossaDepartment of Biomedical Sciences, University of Cagliari, 09042 Monserrato (CA), Italy.ORCID 0000-0002-2849-4052
Azienda Ospedaliera G. Brotzu · ITUniversity of Cagliari · ITUniversity of Illinois Urbana-Champaign · US

Funding

Dr. Pepino is supported by the USDA National Institute of Food and Agriculture (NIFA) Hatch Project 698-921This work has been realized within the research project supported by P.O.R. SARDEGNA F.S.E. 2014-2020-Asse III "Istruzione e Formazione", Obiettivo Tematico: 10, Obiettivo Specifico: 10.5, Azione dell'accordo fi Partenariato:10.5.12 "Avviso di chiamata per il finanziamento di Progetti di ricercar-Anno 2017"University of Cagliari Fondi 5 per mille (Anno 2017)University of Cagliari Fondo Integrativo per la Ricerca (FIR 2019)
6 · The paper itself

Abstract

Bariatric surgery is the most effective long-term treatment for severe obesity and related comorbidities. Although patients who underwent bariatric surgery report changes of taste and smell perception, results from sensory studies are discrepant and limited. Here, we assessed taste and smell functions in 51 patients before, one month, and six months after undergoing bariatric surgery. We used taste strip tests to assess gustatory function (including sweetness, saltiness, sourness, umaminess, bitterness and oleic acid, a fatty stimulus), the "Sniffin' Sticks" test to assess olfactory identification and the 3-Factor Eating Questionnaire to assess eating behavior. We also explored associations between these phenotypes and flavor-related genes. Results showed an overall improvement in taste function (including increased sensitivity to oleic acid and the bitterness of 6-n-propylthiouracil (PROP)) and in olfactory function (which could be related to the increase in PROP and oleic acid sensitivity), an increase in cognitive restraint, and a decrease in disinhibition and hunger after bariatric surgery. These findings indicate that bariatric surgery can have a positive impact on olfactory and gustatory functions and eating behavior (with an important role of genetic factors, such PROP tasting), which in turn might contribute to the success of the intervention.

Indexed as

PhenotypePolymorphism, GeneticAdultBariatric SurgeryCD36 AntigensFeeding BehaviorFemaleHumansLipocalinsMaleObesity, MorbidReceptors, AntigenSmellTasteUracil6-n-propyluracilCD36 AntigensCD36 protein, humanLipocalinsOBP2A protein, humanReceptors, AntigenUracilbariatric surgeryeating behavior cognitive controlgene effectssmelltaste

Identifiers

PMID33467165
PMCPMC7830302
OpenAlexW3123879146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.