Evidence map›Paper›PMID 33467082›Full record

ArticleInternational journal of molecular sciences2021

Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells.

Noemi Monti, Maria Grazia Masiello, Sara Proietti, Angela Catizone, Giulia Ricci, Abdel Halim Harrath, Saleh H Alwasel, Alessandra Cucina, Mariano Bizzarri

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  8. Omics Studies of Tumor Cells under Microgravity Conditions.International journal of molecular sciences · 2024
    Review
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  19. Article
  20. Microgravity and Space Medicine.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Noemi MontiDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Maria Grazia MasielloDepartment of Surgery "Pietro Valdoni", Sapienza University of Rome, 00161 Rome, Italy.
Sara ProiettiDepartment of Surgery "Pietro Valdoni", Sapienza University of Rome, 00161 Rome, Italy.
Angela CatizoneDepartment of Anatomy, Histology, Forensic-Medicine and Orthopedics, Section of Histology and Embryology, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-7836-9495
Giulia RicciDepartment of Experimental Medicine, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-2199-170X
Abdel Halim HarrathDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0002-2170-1303
Saleh H AlwaselDepartment of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Alessandra CucinaDepartment of Surgery "Pietro Valdoni", Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5469-6419
Mariano BizzarriDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-0408-4136
Sapienza University of Rome · ITKing Saud University · SAPoliclinico Umberto I · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

Italian Space Agency (ASI) grant number 2014-010-R.0; grant number 2013-084-R.0;
6 · The paper itself

Abstract

Metazoan living cells exposed to microgravity undergo dramatic changes in morphological and biological properties, which ultimately lead to apoptosis and phenotype reprogramming. However, apoptosis can occur at very different rates depending on the experimental model, and in some cases, cells seem to be paradoxically protected from programmed cell death during weightlessness. These controversial results can be explained by considering the notion that the behavior of adherent cells dramatically diverges in respect to that of detached cells, organized into organoids-like, floating structures. We investigated both normal (MCF10A) and cancerous (MCF-7) breast cells and found that appreciable apoptosis occurs only after 72 h in MCF-7 cells growing in organoid-like structures, in which major modifications of cytoskeleton components were observed. Indeed, preserving cell attachment to the substrate allows cells to upregulate distinct Akt- and ERK-dependent pathways in MCF-7 and MCF-10A cells, respectively. These findings show that survival strategies may differ between cell types but cannot provide sufficient protection against weightlessness-induced apoptosis alone if adhesion to the substrate is perturbed.

Indexed as

ApoptosisWeightlessnessBreast NeoplasmsCell AdhesionCell LineCell SurvivalCytoskeletonExtracellular Matrix ProteinsExtracellular Signal-Regulated MAP KinasesFemaleHumansMCF-7 CellsProto-Oncogene Proteins c-aktSignal TransductionExtracellular Matrix ProteinsExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktAktapoptosiscytoskeletonERKmicrogravityspace biomedicinesurvival pathwaysvinculin

Identifiers

PMID33467082
PMCPMC7829699
OpenAlexW3122401960

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.