Evidence map›Paper›PMID 33467042›Full record

ArticleNutrients2021

Adherence to Mediterranean Diet, Physical Activity and Survival after Prostate Cancer Diagnosis.

Matteo Di Maso, Livia S A Augustin, Federica Toffolutti, Carmen Stocco, Luigino Dal Maso, David J A Jenkins, Neil E Fleshner, Diego Serraino, Jerry Polesel

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Diet quality, eating behaviour, and mental health outcomes of prostate cancer survivors.Journal of cancer survivorship : research and practice · 2025
    Article
  8. Article
  9. Exercise Prescription in Cardio-Oncology.Journal of clinical medicine · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Cells · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Matteo Di MasoDepartment of Clinical Sciences and Community Health, Branch of Medical Statistics, Biometry and Epidemiology "G.A. Maccacaro", Università degli Studi di Milano, via A. Vanzetti 5, 20133 Milan, Italy.ORCID 0000-0002-6481-990X
Livia S A AugustinEpidemiology and Biostatistics Unit, Istituto Nazionale Tumori-IRCCS-"Fondazione G. Pascale", via M. Semmola 1, 80131 Naples, Italy.ORCID 0000-0002-6673-8281
Federica ToffoluttiUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano IRCCS, via F. Gallini 2, 33081 Aviano, Italy.
Carmen StoccoVenetian Cancer Registry, Veneto Region, via J. Avanzo 35, 35131 Padua, Italy.
Luigino Dal MasoUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano IRCCS, via F. Gallini 2, 33081 Aviano, Italy.
David J A JenkinsDepartments of Nutritional Science and Medicine, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0003-1192-9571
Neil E FleshnerDivision of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada.
Diego SerrainoUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano IRCCS, via F. Gallini 2, 33081 Aviano, Italy.
Jerry PoleselUnit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano IRCCS, via F. Gallini 2, 33081 Aviano, Italy.ORCID 0000-0001-9381-1520
Centro di Riferimento Oncologico · ITIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITRegione del Veneto · ITSt. Michael's Hospital · CAUniversity Health Network · CAUniversity of Milan · IT

Funding

Italian Association for Research on Cancer AIRC IG No. 1468Italian Ministry of Health (Ricerca Corrente) no grant number provided
6 · The paper itself

Abstract

Despite the considerable number of studies investigating the Mediterranean diet in prostate cancer (PCa) etiology, very few focused on cancer survival. We assessed the pre-diagnostic diet and physical activity in a cohort of 777 men with PCa diagnosed between 1995 and 2002 in north-eastern Italy; adherence to the Mediterranean diet was evaluated through the Mediterranean Diet Score (MDS). Hazard ratios (HR) of death with confidence intervals (CI) were estimated using the Cox model, adjusting for potential confounders. During 10 years of follow-up, 208 patients (26.8%) died, 75 (9.7%) due to PCa. Patients reporting MDS ≥ 5 showed a higher overall survival than those with MDS < 5 (HR = 0.74; 95% CI: 0.56-0.99). Although high physical activity was not significantly associated with overall survival (HR = 0.79; 95% CI: 0.59-1.07), the HR for all-cause death was the lowest (HR = 0.58; 95% CI: 0.38-0.90) for men reporting MDS ≥ 5 and high physical activity compared to those reporting MDS < 5 and low/moderate physical activity. No association emerged for PCa specific survival. Study findings support the beneficial impact of pre-diagnostic adherence to the Mediterranean diet and physical activity on overall survival; they are mainly driven by risk reduction in non-prostate cancer mortality, which however accounts for about 80% of death in men with PCa.

Indexed as

Diet, MediterraneanPatient ComplianceAgedCohort StudiesExerciseFollow-Up StudiesHumansItalyMaleMiddle AgedProstatic NeoplasmsRisk Reduction BehaviorSurvival RateTime FactorsMediterranean dietphysical activityprostate cancersurvival

Identifiers

PMID33467042
PMCPMC7829941
OpenAlexW3124692581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.