Evidence map›Paper›PMID 33467026›Full record

ArticleMicromachines2021

3D-Printed Microfluidic Droplet Generator with Hydrophilic and Hydrophobic Polymers.

Chandler A Warr, Hunter S Hinnen, Saroya Avery, Rebecca J Cate, Gregory P Nordin, William G Pitt

Abstract read
In one paragraph

Article in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chandler A WarrDepartment of Chemical Engineering, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0002-0589-3798
Hunter S HinnenDepartment of Electrical Engineering, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0003-2728-2303
Saroya AveryDepartment of Electrical Engineering, Brigham Young University, Provo, UT 84602, USA.
Rebecca J CateDepartment of Electrical Engineering, Brigham Young University, Provo, UT 84602, USA.
Gregory P NordinDepartment of Electrical Engineering, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0001-7241-5764
William G PittDepartment of Chemical Engineering, Brigham Young University, Provo, UT 84602, USA.ORCID 0000-0002-6043-3452

Funding

High Density 3D Printed Microfluidics With Open Source Resins for Biomedical ApplicationsR15GM123405 · NIGMS · BRIGHAM YOUNG UNIVERSITY · PI NORDIN, GREGORY P. · 2017 to 2023
$1.3M
NIGMS NIH HHS R15 GM123405NIH HHS R15GM123405; R15GM123405-02
6 · The paper itself

Abstract

Droplet generation has been widely used in conventional two-dimensional (2D) microfluidic devices, and has recently begun to be explored for 3D-printed droplet generators. A major challenge for 3D-printed devices is preventing water-in-oil droplets from sticking to the interior surfaces of the droplet generator when the device is not made from hydrophobic materials. In this study, two approaches were investigated and shown to successfully form droplets in 3D-printed microfluidic devices. First, several printing resin candidates were tested to evaluate their suitability for droplet formation and material properties. We determined that a hexanediol diacrylate/lauryl acrylate (HDDA/LA) resin forms a solid polymer that is sufficiently hydrophobic to prevent aqueous droplets (in a continuous oil flow) from attaching to the device walls. The second approach uses a fully 3D annular channel-in-channel geometry to form microfluidic droplets that do not contact channel walls, and thus, this geometry can be used with hydrophilic resins. Stable droplets were shown to form using the channel-in-channel geometry, and the droplet size and generation frequency for this geometry were explored for various flow rates for the continuous and dispersed phases.

Indexed as

3D printingdroplet generationmicrofluidicssurface properties

Identifiers

PMID33467026
PMCPMC7830873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.