ArticleBrain sciences2021
Using Fractal Dimension Analysis with the Desikan-Killiany Atlas to Assess the Effects of Normal Aging on Subregional Cortex Alterations in Adulthood.
Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cortical complexity estimation using fractal dimension: A systematic review of the literature on clinical and nonclinical samples.The European journal of neuroscience · 2022Pooled it
- Dissociating prefrontal contribution to reactive and proactive aggression: a transcranial direct current stimulation study.European archives of psychiatry and clinical neuroscience · 2026Article
- Article
- Understanding the Temporal Dynamics of Accelerated Brain Aging and Resilient Brain Aging: Insights from Discriminative Event-Based Analysis of UK Biobank Data.Bioengineering (Basel, Switzerland) · 2024Article
- Cortical thickness of the inferior parietal lobule as a potential predictor of relapse in men with alcohol dependence.Brain imaging and behavior · 2024Article
- Fractal Dimension Studies of the Brain Shape in Aging and Neurodegenerative Diseases.Advances in neurobiology · 2024Article
- Fractal Dimension Analysis in Neurological Disorders: An Overview.Advances in neurobiology · 2024Review
- Machine learning models for diagnosing Alzheimer's disease using brain cortical complexity.Frontiers in aging neuroscience · 2024Article
- Exploring Successful Cognitive Aging: Insights Regarding Brain Structure, Function, and Demographics.Brain sciences · 2023Article
- Age-associated sex and asymmetry differentiation in hemispheric and lobar cortical ribbon complexity across adulthood: A UK Biobank imaging study.Human brain mapping · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
Normal aging is associated with functional and structural alterations in the human brain. The effects of normal aging and gender on morphological changes in specific regions of the brain are unknown. The fractal dimension (FD) can be a quantitative measure of cerebral folding. In this study, we used 3D-FD analysis with the Desikan-Killiany (DK) atlas to assess subregional morphological changes in adulthood. A total of 258 participants (112 women and 146 men) aged 30-85 years participated in this study. Participants in the middle-age group exhibited a decreased FD in the lateral frontal lobes, which then spread to the temporal and parietal lobes. Men exhibited an earlier and more significant decrease in FD values, mainly in the right frontal and left parietal lobes. Men exhibited more of a decrease in FD values in the subregions on the left than those in the right, whereas women exhibited more of a decrease in the lateral subregions. Older men were at a higher risk of developing mild cognitive impairment (MCI) and exhibited age-related memory decline earlier than women. Our FD analysis using the DK atlas-based prediagnosis may provide a suitable tool for assessing normal aging and neurodegeneration between groups or in individual patients.
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